MIR548F4

Summary

MIR548F4 (microRNA 548f-4, HGNC:35308) is a microRNA gene on chromosome 7q35.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100313895 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35308
Approved symbol	MIR548F4
Name	microRNA 548f-4
Location	7q35
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-548f-4
Ensembl gene	ENSG00000221442
Ensembl biotype	miRNA
Entrez	100313895
RNAcentral	URS000075A5A4 — miRNA, 105 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408515

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408515 — 1 exons

Exon	Start	End
ENSE00001565150	147378017	147378121

Expression profiles

Bgee: expression breadth broad, 90 present calls, max score 77.90.

Top tissues by expression

90 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
monocyte	CL:0000576	77.90	gold quality
adrenal tissue	UBERON:0018303	77.35	gold quality
blood	UBERON:0000178	76.87	gold quality
endometrium	UBERON:0001295	76.50	gold quality
calcaneal tendon	UBERON:0003701	76.47	gold quality
tonsil	UBERON:0002372	74.85	gold quality
pancreas	UBERON:0001264	74.19	gold quality
gastrocnemius	UBERON:0001388	74.04	gold quality
right adrenal gland cortex	UBERON:0035827	73.89	gold quality
bone marrow	UBERON:0002371	73.43	gold quality
body of pancreas	UBERON:0001150	73.22	gold quality
stomach	UBERON:0000945	72.66	gold quality
ectocervix	UBERON:0012249	71.45	gold quality
right ovary	UBERON:0002118	71.38	gold quality
mucosa of stomach	UBERON:0001199	71.28	gold quality
body of stomach	UBERON:0001161	71.22	gold quality
ascending aorta	UBERON:0001496	71.07	gold quality
heart left ventricle	UBERON:0002084	71.00	gold quality
adrenal gland	UBERON:0002369	70.93	gold quality
tibial artery	UBERON:0007610	70.89	gold quality
right lobe of liver	UBERON:0001114	70.88	gold quality
heart	UBERON:0000948	70.78	gold quality
thoracic aorta	UBERON:0001515	70.71	gold quality
right atrium auricular region	UBERON:0006631	70.55	gold quality
right adrenal gland	UBERON:0001233	69.82	gold quality
kidney	UBERON:0002113	69.67	gold quality
lower esophagus mucosa	UBERON:0035834	69.59	gold quality
vagina	UBERON:0000996	69.39	gold quality
lower esophagus muscularis layer	UBERON:0035833	69.13	gold quality
left adrenal gland	UBERON:0001234	69.03	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.32

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.