MIR548F5

Summary

MIR548F5 (microRNA 548f-5, HGNC:35309) is a microRNA gene on chromosome Xp21.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302239 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35309
Approved symbol	MIR548F5
Name	microRNA 548f-5
Location	Xp21.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-548f-5
Ensembl gene	ENSG00000221348
Ensembl biotype	miRNA
Entrez	100302239
RNAcentral	URS000075EBAA — miRNA, 86 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408421

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408421 — 1 exons

Exon	Start	End
ENSE00001565056	32641474	32641559

Expression profiles

Bgee: expression breadth broad, 26 present calls, max score 79.07.

Top tissues by expression

26 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
calcaneal tendon	UBERON:0003701	79.07	gold quality
heart left ventricle	UBERON:0002084	74.21	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	73.04	gold quality
gastrocnemius	UBERON:0001388	72.71	gold quality
heart	UBERON:0000948	70.06	gold quality
muscle layer of sigmoid colon	UBERON:0035805	69.88	gold quality
left adrenal gland	UBERON:0001234	69.58	gold quality
body of stomach	UBERON:0001161	68.64	gold quality
ascending aorta	UBERON:0001496	67.23	gold quality
Ammon’s horn	UBERON:0001954	66.93	gold quality
right atrium auricular region	UBERON:0006631	65.76	gold quality
colon	UBERON:0001155	65.52	gold quality
stomach	UBERON:0000945	65.46	gold quality
popliteal artery	UBERON:0002250	64.66	gold quality
left coronary artery	UBERON:0001626	64.56	gold quality
skin of abdomen	UBERON:0001416	64.53	gold quality
tibial artery	UBERON:0007610	64.30	gold quality
right frontal lobe	UBERON:0002810	64.24	gold quality
left ovary	UBERON:0002119	63.88	gold quality
minor salivary gland	UBERON:0001830	62.81	gold quality
left lobe of thyroid gland	UBERON:0001120	62.34	gold quality
tibial nerve	UBERON:0001323	62.12	gold quality
omental fat pad	UBERON:0010414	59.71	gold quality
thyroid gland	UBERON:0002046	58.95	gold quality
descending thoracic aorta	UBERON:0002345	56.97	gold quality
corpus callosum	UBERON:0002336	50.00	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.40

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.