MIR548G

Summary

MIR548G (microRNA 548g, HGNC:35326) is a microRNA gene on chromosome 4q31.22.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100313938 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35326
Approved symbol	MIR548G
Name	microRNA 548g
Location	4q31.22
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-548g
Ensembl gene	ENSG00000221369
Ensembl biotype	miRNA
Entrez	100313938
RNAcentral	URS000075D0BD — miRNA, 89 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408442

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408442 — 1 exons

Exon	Start	End
ENSE00001565077	147344629	147344717

Expression profiles

Bgee: expression breadth broad, 25 present calls, max score 82.59.

Top tissues by expression

25 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	82.59	gold quality
blood	UBERON:0000178	79.39	gold quality
islet of Langerhans	UBERON:0000006	76.54	gold quality
lower esophagus muscularis layer	UBERON:0035833	76.31	gold quality
endometrium	UBERON:0001295	74.30	gold quality
calcaneal tendon	UBERON:0003701	72.23	gold quality
right coronary artery	UBERON:0001625	68.27	gold quality
hypothalamus	UBERON:0001898	67.70	gold quality
subcutaneous adipose tissue	UBERON:0002190	67.56	gold quality
transverse colon	UBERON:0001157	66.32	gold quality
upper lobe of left lung	UBERON:0008952	65.03	gold quality
vagina	UBERON:0000996	63.89	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	63.36	gold quality
lung	UBERON:0002048	63.27	gold quality
thyroid gland	UBERON:0002046	62.78	gold quality
left lobe of thyroid gland	UBERON:0001120	62.62	gold quality
esophagus mucosa	UBERON:0002469	61.87	gold quality
omental fat pad	UBERON:0010414	61.48	gold quality
cerebellar hemisphere	UBERON:0002245	60.50	gold quality
skin of leg	UBERON:0001511	58.86	gold quality
caudate nucleus	UBERON:0001873	54.54	gold quality
right testis	UBERON:0004534	46.38	gold quality
testis	UBERON:0000473	44.09	gold quality
left testis	UBERON:0004533	43.71	gold quality
corpus callosum	UBERON:0002336	43.64	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.49

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• MicroRNA miR-548g-3p directly regulates dengue virus replication. (PMID:25499200)
• CircFAT1(e2) may play a role as a tumor suppressor in gastric cancer cells by regulating the miR-548g/RUNX1 axis in the cytoplasm and targeting YBX1 in the nucleus. (PMID:30419346)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.