MIR548H1

Summary

MIR548H1 (microRNA 548h-1, HGNC:35342) is a microRNA gene on chromosome 14q23.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100313830 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35342
Approved symbol	MIR548H1
Name	microRNA 548h-1
Location	14q23.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-548h-1
Ensembl gene	ENSG00000221537
Ensembl biotype	miRNA
Entrez	100313830
RNAcentral	URS000075DC3C — miRNA, 102 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408610

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408610 — 1 exons

Exon	Start	End
ENSE00001565245	64095024	64095125

Expression profiles

Bgee: expression breadth broad, 94 present calls, max score 93.36.

Top tissues by expression

94 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	93.36	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	87.60	gold quality
calcaneal tendon	UBERON:0003701	79.27	gold quality
blood	UBERON:0000178	78.84	gold quality
kidney	UBERON:0002113	78.51	gold quality
bone marrow	UBERON:0002371	76.92	gold quality
endometrium	UBERON:0001295	76.18	gold quality
muscle of leg	UBERON:0001383	75.83	gold quality
adult mammalian kidney	UBERON:0000082	75.11	gold quality
gastrocnemius	UBERON:0001388	74.43	gold quality
islet of Langerhans	UBERON:0000006	73.74	gold quality
monocyte	CL:0000576	73.67	gold quality
liver	UBERON:0002107	73.56	gold quality
stomach	UBERON:0000945	73.49	gold quality
left uterine tube	UBERON:0001303	72.72	gold quality
heart	UBERON:0000948	71.42	gold quality
left coronary artery	UBERON:0001626	71.34	gold quality
right lobe of liver	UBERON:0001114	71.17	gold quality
left adrenal gland cortex	UBERON:0035825	70.85	gold quality
adrenal tissue	UBERON:0018303	70.81	gold quality
ascending aorta	UBERON:0001496	70.73	gold quality
tibial artery	UBERON:0007610	70.68	gold quality
body of pancreas	UBERON:0001150	70.61	gold quality
heart left ventricle	UBERON:0002084	70.45	gold quality
thoracic aorta	UBERON:0001515	70.43	gold quality
body of stomach	UBERON:0001161	69.92	gold quality
right coronary artery	UBERON:0001625	69.90	gold quality
left adrenal gland	UBERON:0001234	69.87	gold quality
right atrium auricular region	UBERON:0006631	69.41	gold quality
lower esophagus muscularis layer	UBERON:0035833	69.34	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.84

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.