MIR548H2

Summary

MIR548H2 (microRNA 548h-2, HGNC:35343) is a microRNA gene on chromosome 16p13.13.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100313773 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35343
Approved symbol	MIR548H2
Name	microRNA 548h-2
Location	16p13.13
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-548h-2
Ensembl gene	ENSG00000221801
Ensembl biotype	miRNA
Entrez	100313773
RNAcentral	URS000075EC57 — miRNA, 88 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408874

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408874 — 1 exons

Exon	Start	End
ENSE00001808304	11306440	11306527

Expression profiles

Bgee: expression breadth broad, 96 present calls, max score 80.10.

Top tissues by expression

96 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
vermiform appendix	UBERON:0001154	80.10	gold quality
adrenal tissue	UBERON:0018303	78.19	gold quality
endometrium	UBERON:0001295	76.98	gold quality
corpus callosum	UBERON:0002336	76.10	gold quality
calcaneal tendon	UBERON:0003701	75.72	gold quality
muscle of leg	UBERON:0001383	75.42	gold quality
liver	UBERON:0002107	75.09	gold quality
lower esophagus mucosa	UBERON:0035834	74.87	gold quality
leukocyte	CL:0000738	74.84	gold quality
lymph node	UBERON:0000029	74.70	gold quality
monocyte	CL:0000576	74.31	gold quality
islet of Langerhans	UBERON:0000006	74.18	gold quality
gastrocnemius	UBERON:0001388	73.94	gold quality
kidney	UBERON:0002113	73.73	gold quality
right lobe of liver	UBERON:0001114	73.16	gold quality
right lobe of thyroid gland	UBERON:0001119	73.15	gold quality
right hemisphere of cerebellum	UBERON:0014890	72.76	gold quality
blood	UBERON:0000178	72.50	gold quality
pancreas	UBERON:0001264	71.89	gold quality
left coronary artery	UBERON:0001626	71.54	gold quality
right adrenal gland cortex	UBERON:0035827	71.48	gold quality
cerebellar hemisphere	UBERON:0002245	71.33	gold quality
heart left ventricle	UBERON:0002084	71.26	gold quality
adult mammalian kidney	UBERON:0000082	71.23	gold quality
fallopian tube	UBERON:0003889	70.88	gold quality
metanephros cortex	UBERON:0010533	70.87	gold quality
right uterine tube	UBERON:0001302	70.67	gold quality
body of pancreas	UBERON:0001150	70.49	gold quality
stomach	UBERON:0000945	70.46	gold quality
heart	UBERON:0000948	70.37	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.15

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.