MIR548H3

Summary

MIR548H3 (microRNA 548h-3, HGNC:35344) is a microRNA gene on chromosome 17p12.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302287 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35344
Approved symbol	MIR548H3
Name	microRNA 548h-3
Location	17p12
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-548h-3
Ensembl gene	ENSG00000221698
Ensembl biotype	miRNA
Entrez	100302287
RNAcentral	URS000075DADE — miRNA, 118 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408771

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408771 — 1 exons

Exon	Start	End
ENSE00001565406	13543529	13543646

Expression profiles

Bgee: expression breadth broad, 79 present calls, max score 82.31.

Top tissues by expression

79 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
monocyte	CL:0000576	82.31	gold quality
corpus callosum	UBERON:0002336	76.44	gold quality
adrenal tissue	UBERON:0018303	76.38	gold quality
stomach	UBERON:0000945	75.63	gold quality
blood	UBERON:0000178	75.14	gold quality
endometrium	UBERON:0001295	75.07	gold quality
placenta	UBERON:0001987	72.48	gold quality
left coronary artery	UBERON:0001626	72.03	gold quality
muscle of leg	UBERON:0001383	71.38	gold quality
gastrocnemius	UBERON:0001388	71.02	gold quality
heart	UBERON:0000948	70.54	gold quality
calcaneal tendon	UBERON:0003701	70.27	gold quality
lung	UBERON:0002048	70.14	gold quality
right atrium auricular region	UBERON:0006631	70.06	gold quality
myometrium	UBERON:0001296	69.26	gold quality
ascending aorta	UBERON:0001496	69.12	gold quality
body of pancreas	UBERON:0001150	68.93	gold quality
heart left ventricle	UBERON:0002084	68.69	gold quality
colon	UBERON:0001155	68.63	gold quality
body of stomach	UBERON:0001161	68.55	gold quality
intestine	UBERON:0000160	68.53	gold quality
liver	UBERON:0002107	68.52	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	68.47	gold quality
muscle layer of sigmoid colon	UBERON:0035805	68.33	gold quality
esophagus mucosa	UBERON:0002469	68.09	gold quality
right ovary	UBERON:0002118	67.97	gold quality
popliteal artery	UBERON:0002250	67.86	gold quality
right adrenal gland cortex	UBERON:0035827	67.77	gold quality
thoracic mammary gland	UBERON:0005200	67.57	gold quality
Brodmann (1909) area 9	UBERON:0013540	67.57	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.49

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Paralogs (25): MIR548AA1 (ENSG00000207704), MIR579 (ENSG00000207956), MIR548P (ENSG00000221263), MIR548K (ENSG00000221333), MIR548F3 (ENSG00000221436), MIR548F1 (ENSG00000221594), MIR548N (ENSG00000221669), MIR548AN (ENSG00000263515), MIR548X2 (ENSG00000263581), MIR548AX (ENSG00000263652), MIR548AS (ENSG00000263741), MIR548AV (ENSG00000263750), MIR548S (ENSG00000265056), MIR548AQ (ENSG00000265470), MIR548AG2 (ENSG00000265617), MIR548AJ1 (ENSG00000265669), MIR548AG1 (ENSG00000265829), MIR548X (ENSG00000265841), MIR548Z (ENSG00000266016), MIR548H5 (ENSG00000266807), MIR548AE1 (ENSG00000266808), MIR548O2 (ENSG00000275453), MIR548AY (ENSG00000276147), MIR548AZ (ENSG00000276479), MIR548AH (ENSG00000283682)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.