MIR548H4

Summary

MIR548H4 (microRNA 548h-4, HGNC:35345) is a microRNA gene on chromosome 8p21.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100313884 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35345
Approved symbol	MIR548H4
Name	microRNA 548h-4
Location	8p21.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-548h-4
Ensembl gene	ENSG00000221616
Ensembl biotype	miRNA
Entrez	100313884
RNAcentral	URS000075DB60 — miRNA, 111 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408689

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408689 — 1 exons

Exon	Start	End
ENSE00001565324	27048853	27048963

Expression profiles

Bgee: expression breadth broad, 68 present calls, max score 91.66.

Top tissues by expression

68 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	91.66	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	89.35	gold quality
adult mammalian kidney	UBERON:0000082	86.71	gold quality
kidney	UBERON:0002113	85.84	gold quality
corpus callosum	UBERON:0002336	84.31	gold quality
liver	UBERON:0002107	84.19	gold quality
stomach	UBERON:0000945	78.00	gold quality
monocyte	CL:0000576	75.87	gold quality
blood	UBERON:0000178	75.65	gold quality
heart left ventricle	UBERON:0002084	74.56	gold quality
heart	UBERON:0000948	74.12	gold quality
gastrocnemius	UBERON:0001388	73.86	gold quality
sural nerve	UBERON:0015488	73.44	gold quality
body of pancreas	UBERON:0001150	73.05	gold quality
left coronary artery	UBERON:0001626	72.86	gold quality
calcaneal tendon	UBERON:0003701	72.15	gold quality
muscle layer of sigmoid colon	UBERON:0035805	71.23	gold quality
body of stomach	UBERON:0001161	70.90	gold quality
endometrium	UBERON:0001295	70.86	gold quality
intestine	UBERON:0000160	70.72	gold quality
body of uterus	UBERON:0009853	70.53	gold quality
right lobe of liver	UBERON:0001114	69.75	gold quality
lower esophagus muscularis layer	UBERON:0035833	69.64	gold quality
colon	UBERON:0001155	69.44	gold quality
right atrium auricular region	UBERON:0006631	69.44	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	69.04	gold quality
subcutaneous adipose tissue	UBERON:0002190	68.72	gold quality
lung	UBERON:0002048	68.51	gold quality
Brodmann (1909) area 9	UBERON:0013540	68.35	gold quality
tibial artery	UBERON:0007610	68.26	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.65

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.