MIR548I1

Summary

MIR548I1 (microRNA 548i-1, HGNC:35352) is a microRNA gene on chromosome 3q21.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302204 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35352
Approved symbol	MIR548I1
Name	microRNA 548i-1
Location	3q21.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-548i-1
Ensembl gene	ENSG00000221737
Ensembl biotype	miRNA
Entrez	100302204
RNAcentral	URS000075A33A — miRNA, 149 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408810

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408810 — 1 exons

Exon	Start	End
ENSE00001808765	125790404	125790552

Expression profiles

Bgee: expression breadth ubiquitous, 120 present calls, max score 99.69.

Top tissues by expression

120 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right uterine tube	UBERON:0001302	99.69	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	99.55	gold quality
endocervix	UBERON:0000458	93.05	gold quality
left ovary	UBERON:0002119	92.55	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	92.11	gold quality
right ovary	UBERON:0002118	91.86	gold quality
left uterine tube	UBERON:0001303	91.84	gold quality
fallopian tube	UBERON:0003889	91.33	gold quality
endometrium	UBERON:0001295	91.30	gold quality
ovary	UBERON:0000992	91.01	gold quality
pituitary gland	UBERON:0000007	90.62	gold quality
mucosa of stomach	UBERON:0001199	90.60	gold quality
adenohypophysis	UBERON:0002196	89.21	gold quality
skin of leg	UBERON:0001511	88.25	gold quality
body of uterus	UBERON:0009853	88.03	gold quality
vagina	UBERON:0000996	88.01	gold quality
sural nerve	UBERON:0015488	87.96	gold quality
tibial nerve	UBERON:0001323	87.82	gold quality
zone of skin	UBERON:0000014	87.74	gold quality
superior frontal gyrus	UBERON:0002661	87.49	gold quality
ectocervix	UBERON:0012249	87.45	gold quality
skin of abdomen	UBERON:0001416	86.97	gold quality
left lobe of thyroid gland	UBERON:0001120	86.48	gold quality
thyroid gland	UBERON:0002046	85.98	gold quality
right lung	UBERON:0002167	85.68	gold quality
myometrium	UBERON:0001296	85.16	gold quality
metanephros cortex	UBERON:0010533	84.96	gold quality
small intestine Peyer’s patch	UBERON:0003454	84.05	gold quality
transverse colon	UBERON:0001157	83.98	gold quality
rectum	UBERON:0001052	83.65	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.24

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• circNFATC3 sponges miR-548I acts as a ceRNA to protect NFATC3 itself and suppressed hepatocellular carcinoma progression. (PMID:32667692)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.