MIR548I2

Summary

MIR548I2 (microRNA 548i-2, HGNC:35353) is a microRNA gene on chromosome 4p16.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302277 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35353
Approved symbol	MIR548I2
Name	microRNA 548i-2
Location	4p16.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-548i-2
Ensembl gene	ENSG00000221275
Ensembl biotype	miRNA
Entrez	100302277
RNAcentral	URS000075E2FD — miRNA, 149 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408348

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408348 — 1 exons

Exon	Start	End
ENSE00001564983	9556168	9556316

Expression profiles

Bgee: expression breadth broad, 88 present calls, max score 94.80.

Top tissues by expression

88 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	94.80	gold quality
monocyte	CL:0000576	85.31	gold quality
right uterine tube	UBERON:0001302	83.40	gold quality
prefrontal cortex	UBERON:0000451	81.94	gold quality
calcaneal tendon	UBERON:0003701	73.76	gold quality
adult mammalian kidney	UBERON:0000082	72.34	gold quality
right ovary	UBERON:0002118	72.30	gold quality
ovary	UBERON:0000992	70.85	gold quality
left ovary	UBERON:0002119	70.62	gold quality
endometrium	UBERON:0001295	70.44	gold quality
urinary bladder	UBERON:0001255	69.90	gold quality
fundus of stomach	UBERON:0001160	69.62	gold quality
stomach	UBERON:0000945	69.23	gold quality
myometrium	UBERON:0001296	68.77	gold quality
ectocervix	UBERON:0012249	68.73	gold quality
body of uterus	UBERON:0009853	67.98	gold quality
blood	UBERON:0000178	67.14	gold quality
right atrium auricular region	UBERON:0006631	66.75	gold quality
kidney	UBERON:0002113	66.63	gold quality
adenohypophysis	UBERON:0002196	66.39	gold quality
hypothalamus	UBERON:0001898	65.99	gold quality
right lobe of thyroid gland	UBERON:0001119	65.90	gold quality
Brodmann (1909) area 9	UBERON:0013540	65.83	gold quality
body of stomach	UBERON:0001161	65.46	gold quality
islet of Langerhans	UBERON:0000006	65.43	gold quality
left adrenal gland cortex	UBERON:0035825	65.39	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	65.12	gold quality
ascending aorta	UBERON:0001496	64.76	gold quality
thoracic aorta	UBERON:0001515	64.55	gold quality
Ammon’s horn	UBERON:0001954	64.53	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.44

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.