MIR548I3

Summary

MIR548I3 (microRNA 548i-3, HGNC:35354) is a microRNA gene on chromosome 8p23.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302186 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35354
Approved symbol	MIR548I3
Name	microRNA 548i-3
Location	8p23.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-548i-3
Ensembl gene	ENSG00000221305
Ensembl biotype	miRNA
Entrez	100302186
RNAcentral	URS000075B6B2 — miRNA, 149 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408378

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408378 — 1 exons

Exon	Start	End
ENSE00001807555	8088941	8089089

Expression profiles

Bgee: expression breadth broad, 100 present calls, max score 81.93.

Top tissues by expression

100 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
ectocervix	UBERON:0012249	81.93	gold quality
tibial nerve	UBERON:0001323	79.90	gold quality
right coronary artery	UBERON:0001625	77.99	gold quality
left uterine tube	UBERON:0001303	76.65	gold quality
adrenal tissue	UBERON:0018303	74.18	gold quality
bone marrow	UBERON:0002371	73.84	gold quality
cortex of kidney	UBERON:0001225	73.81	gold quality
pituitary gland	UBERON:0000007	72.79	gold quality
myometrium	UBERON:0001296	72.79	gold quality
left adrenal gland cortex	UBERON:0035825	72.31	gold quality
skin of abdomen	UBERON:0001416	72.14	gold quality
Brodmann (1909) area 9	UBERON:0013540	72.12	gold quality
left ovary	UBERON:0002119	71.74	gold quality
left lobe of thyroid gland	UBERON:0001120	71.64	gold quality
primary visual cortex	UBERON:0002436	71.63	gold quality
skin of leg	UBERON:0001511	71.55	gold quality
body of pancreas	UBERON:0001150	71.11	gold quality
tibial artery	UBERON:0007610	71.11	gold quality
popliteal artery	UBERON:0002250	71.05	gold quality
prefrontal cortex	UBERON:0000451	70.87	gold quality
monocyte	CL:0000576	70.58	gold quality
endometrium	UBERON:0001295	70.48	gold quality
skeletal muscle tissue	UBERON:0001134	70.42	gold quality
smooth muscle tissue	UBERON:0001135	70.17	gold quality
right lobe of thyroid gland	UBERON:0001119	70.05	gold quality
blood	UBERON:0000178	69.93	gold quality
vermiform appendix	UBERON:0001154	69.90	gold quality
ovary	UBERON:0000992	69.47	gold quality
vagina	UBERON:0000996	69.12	gold quality
saliva-secreting gland	UBERON:0001044	69.10	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.17

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.