MIR548I4

Summary

MIR548I4 (microRNA 548i-4, HGNC:35355) is a microRNA gene on chromosome Xq21.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302191 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35355
Approved symbol	MIR548I4
Name	microRNA 548i-4
Location	Xq21.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-548i-4
Ensembl gene	ENSG00000221494
Ensembl biotype	miRNA
Entrez	100302191
RNAcentral	URS000075E823 — miRNA, 77 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408567

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408567 — 1 exons

Exon	Start	End
ENSE00001565202	84225752	84225828

Expression profiles

Bgee: expression breadth tissue_specific, 6 present calls, max score 62.18.

Top tissues by expression

6 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
hypothalamus	UBERON:0001898	62.18	gold quality
right frontal lobe	UBERON:0002810	61.80	gold quality
ascending aorta	UBERON:0001496	61.50	gold quality
Brodmann (1909) area 9	UBERON:0013540	59.17	gold quality
tibial nerve	UBERON:0001323	55.01	gold quality
colon	UBERON:0001155	54.19	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.49

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.