MIR548J

Summary

MIR548J (microRNA 548j, HGNC:35276) is a microRNA gene on chromosome 22q12.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100313914 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35276
Approved symbol	MIR548J
Name	microRNA 548j
Location	22q12.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-548j
Ensembl gene	ENSG00000221760
Ensembl biotype	miRNA
Entrez	100313914
RNAcentral	URS000075C407 — miRNA, 112 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408833

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408833 — 1 exons

Exon	Start	End
ENSE00001565468	26555212	26555323

Expression profiles

Bgee: expression breadth broad, 70 present calls, max score 79.66.

Top tissues by expression

70 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
amygdala	UBERON:0001876	79.66	gold quality
myometrium	UBERON:0001296	79.17	gold quality
blood	UBERON:0000178	78.02	gold quality
monocyte	CL:0000576	77.14	gold quality
adult mammalian kidney	UBERON:0000082	75.67	gold quality
body of pancreas	UBERON:0001150	74.69	gold quality
muscle of leg	UBERON:0001383	74.69	gold quality
gastrocnemius	UBERON:0001388	74.55	gold quality
kidney	UBERON:0002113	74.10	gold quality
liver	UBERON:0002107	73.69	gold quality
lymph node	UBERON:0000029	72.63	gold quality
ascending aorta	UBERON:0001496	71.20	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	70.24	gold quality
thoracic aorta	UBERON:0001515	70.19	gold quality
body of stomach	UBERON:0001161	70.17	gold quality
tibial artery	UBERON:0007610	70.07	gold quality
endometrium	UBERON:0001295	69.67	gold quality
stomach	UBERON:0000945	69.15	gold quality
lower esophagus muscularis layer	UBERON:0035833	68.85	gold quality
adrenal tissue	UBERON:0018303	68.77	gold quality
heart left ventricle	UBERON:0002084	68.53	gold quality
heart	UBERON:0000948	68.48	gold quality
omental fat pad	UBERON:0010414	68.46	gold quality
vagina	UBERON:0000996	68.27	gold quality
subcutaneous adipose tissue	UBERON:0002190	67.67	gold quality
colon	UBERON:0001155	67.65	gold quality
intestine	UBERON:0000160	67.48	gold quality
body of uterus	UBERON:0009853	67.39	gold quality
left adrenal gland	UBERON:0001234	67.31	gold quality
right hemisphere of cerebellum	UBERON:0014890	66.58	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.32

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• MiR-548j, miR-548m, and miR-548d-5p have homologous binding sites in the mRNA of PTPN12 orthologous genes which encode PRTRSC, TEATDI, and STASAT oligopeptides, respectively (PMID:23957009)
• miR-548j-5p regulates angiogenesis in peripheral artery disease. (PMID:35039547)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.