MIR548L

Summary

MIR548L (microRNA 548l, HGNC:35292) is a microRNA gene on chromosome 11q21.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302275 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35292
Approved symbol	MIR548L
Name	microRNA 548l
Location	11q21
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-548l
Ensembl gene	ENSG00000221230
Ensembl biotype	miRNA
Entrez	100302275
RNAcentral	URS000075B8B6 — miRNA, 86 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408303

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408303 — 1 exons

Exon	Start	End
ENSE00001564938	94466495	94466580

Expression profiles

Bgee: expression breadth broad, 93 present calls, max score 99.55.

Top tissues by expression

93 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	99.55	gold quality
bone marrow	UBERON:0002371	79.31	gold quality
calcaneal tendon	UBERON:0003701	79.07	gold quality
lymph node	UBERON:0000029	78.01	gold quality
blood	UBERON:0000178	77.94	gold quality
endometrium	UBERON:0001295	77.16	gold quality
gastrocnemius	UBERON:0001388	73.71	gold quality
kidney	UBERON:0002113	73.37	gold quality
liver	UBERON:0002107	73.10	gold quality
prefrontal cortex	UBERON:0000451	72.65	gold quality
stomach	UBERON:0000945	72.33	gold quality
body of pancreas	UBERON:0001150	71.89	gold quality
monocyte	CL:0000576	71.25	gold quality
heart left ventricle	UBERON:0002084	71.22	gold quality
right lobe of liver	UBERON:0001114	70.97	gold quality
heart	UBERON:0000948	70.12	gold quality
body of stomach	UBERON:0001161	69.96	gold quality
gall bladder	UBERON:0002110	69.90	gold quality
islet of Langerhans	UBERON:0000006	69.86	gold quality
skin of abdomen	UBERON:0001416	69.51	gold quality
right uterine tube	UBERON:0001302	69.37	gold quality
popliteal artery	UBERON:0002250	68.88	gold quality
tibial artery	UBERON:0007610	68.87	gold quality
right atrium auricular region	UBERON:0006631	68.78	gold quality
zone of skin	UBERON:0000014	68.65	gold quality
adrenal gland	UBERON:0002369	68.58	gold quality
minor salivary gland	UBERON:0001830	68.52	gold quality
left coronary artery	UBERON:0001626	68.43	gold quality
left adrenal gland	UBERON:0001234	68.33	gold quality
subcutaneous adipose tissue	UBERON:0002190	68.33	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.48

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• Low miR-548l expression is associated with lymph node metastasis of non-small cell lung cancer. (PMID:25245053)
• Studied the miRNA expression in human hepatocellular carcinoma cell lines; 13 differentially expressed miRNAs were identified between MHCC97-H and MHCC97-L cells; and the same results were found in clinical samples. Found that ST3GAL5 was the direct target of miR-26a, miR-548l and miR-34a. (PMID:28218742)
• Bioinformatics analysis of miRNAs in the neuroblastoma 11q-deleted region reveals a role of miR-548l in both 11q-deleted and MYCN amplified tumour cells. (PMID:36396668)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.