MIR548M

Summary

MIR548M (microRNA 548m, HGNC:35331) is a microRNA gene on chromosome Xq21.33.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100313772 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35331
Approved symbol	MIR548M
Name	microRNA 548m
Location	Xq21.33
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-548m
Ensembl gene	ENSG00000221187
Ensembl biotype	miRNA
Entrez	100313772
RNAcentral	URS000075B476 — miRNA, 86 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408260

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408260 — 1 exons

Exon	Start	End
ENSE00001564895	95063141	95063226

Expression profiles

Bgee: expression breadth tissue_specific, 9 present calls, max score 81.64.

Top tissues by expression

9 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
intestine	UBERON:0000160	81.64	gold quality
lung	UBERON:0002048	76.65	gold quality
blood	UBERON:0000178	73.39	gold quality
tibial nerve	UBERON:0001323	72.01	gold quality
body of pancreas	UBERON:0001150	68.69	gold quality
esophagus mucosa	UBERON:0002469	66.87	gold quality
cerebellar hemisphere	UBERON:0002245	62.82	gold quality
left lobe of thyroid gland	UBERON:0001120	59.38	gold quality
right frontal lobe	UBERON:0002810	54.21	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.33

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• MRNAs of PTPN12, MSH6, and ZEB1 orthologous genes from different animal species have binding sites for hsa-miR-1279 which consist of homologous oligonucleotides encoding similar human oligopeptides (PMID:23957009)
• stroma triggered a c-Myc/miR-548m feed-forward loop, linking sustained c-Myc activation, miR-548m downregulation, and subsequent HDAC6 upregulation and stroma-mediated cell survival and lymphoma progression in lymphoma cell lines (PMID:24216476)
• Modulation of miR-548m encoded by X chromosome on the PTEN pathway in systemic lupus erythematosus. (PMID:33635226)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.