MIR548N

Summary

MIR548N (microRNA 548n, HGNC:35330) is a microRNA gene on chromosome 7p14.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302152 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35330
Approved symbol	MIR548N
Name	microRNA 548n
Location	7p14.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-548n
Ensembl gene	ENSG00000221669
Ensembl biotype	miRNA
Entrez	100302152
RNAcentral	URS000075B760 — miRNA, 75 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408742

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408742 — 1 exons

Exon	Start	End
ENSE00001565377	34940760	34940834

Expression profiles

Bgee: expression breadth ubiquitous, 102 present calls, max score 76.86.

Top tissues by expression

249 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	76.86	gold quality
monocyte	CL:0000576	73.41	gold quality
calcaneal tendon	UBERON:0003701	72.99	gold quality
mononuclear cell	CL:0000842	72.92	gold quality
right lobe of liver	UBERON:0001114	69.11	gold quality
left coronary artery	UBERON:0001626	68.06	gold quality
right atrium auricular region	UBERON:0006631	66.68	gold quality
body of stomach	UBERON:0001161	66.67	gold quality
tibial artery	UBERON:0007610	66.37	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	65.79	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	65.77	gold quality
right hemisphere of cerebellum	UBERON:0014890	65.26	gold quality
muscle layer of sigmoid colon	UBERON:0035805	65.16	gold quality
ascending aorta	UBERON:0001496	64.90	gold quality
lower esophagus	UBERON:0013473	64.81	gold quality
skin of abdomen	UBERON:0001416	64.80	gold quality
transverse colon	UBERON:0001157	64.69	gold quality
lower esophagus muscularis layer	UBERON:0035833	64.52	gold quality
body of pancreas	UBERON:0001150	64.01	gold quality
right frontal lobe	UBERON:0002810	63.58	gold quality
skin of leg	UBERON:0001511	62.98	gold quality
left ovary	UBERON:0002119	61.84	gold quality
gastrocnemius	UBERON:0001388	61.79	gold quality
small intestine Peyer’s patch	UBERON:0003454	61.56	gold quality
minor salivary gland	UBERON:0001830	61.45	gold quality
aorta	UBERON:0000947	61.39	gold quality
buccal mucosa cell	CL:0002336	61.10	silver quality
cerebellar hemisphere	UBERON:0002245	60.52	gold quality
endocervix	UBERON:0000458	60.42	gold quality
tibia	UBERON:0000979	60.42	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.34

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Paralogs (25): MIR548AA1 (ENSG00000207704), MIR579 (ENSG00000207956), MIR548P (ENSG00000221263), MIR548K (ENSG00000221333), MIR548F3 (ENSG00000221436), MIR548F1 (ENSG00000221594), MIR548H3 (ENSG00000221698), MIR548AN (ENSG00000263515), MIR548X2 (ENSG00000263581), MIR548AX (ENSG00000263652), MIR548AS (ENSG00000263741), MIR548AV (ENSG00000263750), MIR548S (ENSG00000265056), MIR548AQ (ENSG00000265470), MIR548AG2 (ENSG00000265617), MIR548AJ1 (ENSG00000265669), MIR548AG1 (ENSG00000265829), MIR548X (ENSG00000265841), MIR548Z (ENSG00000266016), MIR548H5 (ENSG00000266807), MIR548AE1 (ENSG00000266808), MIR548O2 (ENSG00000275453), MIR548AY (ENSG00000276147), MIR548AZ (ENSG00000276479), MIR548AH (ENSG00000283682)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.