MIR548O

Summary

MIR548O (microRNA 548o, HGNC:35333) is a microRNA gene on chromosome 7q22.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100313829 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35333
Approved symbol	MIR548O
Name	microRNA 548o
Location	7q22.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-548o
Ensembl gene	ENSG00000221510
Ensembl biotype	miRNA
Entrez	100313829
RNAcentral	URS000075D1AE — miRNA, 114 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408583

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408583 — 1 exons

Exon	Start	End
ENSE00001565218	102405742	102405855

Expression profiles

Bgee: expression breadth broad, 87 present calls, max score 99.35.

Top tissues by expression

87 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	99.35	gold quality
corpus callosum	UBERON:0002336	87.03	gold quality
calcaneal tendon	UBERON:0003701	78.15	gold quality
adrenal tissue	UBERON:0018303	77.50	gold quality
monocyte	CL:0000576	77.15	gold quality
blood	UBERON:0000178	77.15	gold quality
bone marrow	UBERON:0002371	76.65	gold quality
islet of Langerhans	UBERON:0000006	76.36	gold quality
granulocyte	CL:0000094	76.13	gold quality
muscle of leg	UBERON:0001383	74.62	gold quality
kidney	UBERON:0002113	74.25	gold quality
urinary bladder	UBERON:0001255	73.24	gold quality
gastrocnemius	UBERON:0001388	72.73	gold quality
body of pancreas	UBERON:0001150	72.37	gold quality
lymph node	UBERON:0000029	72.12	gold quality
stomach	UBERON:0000945	71.97	gold quality
endometrium	UBERON:0001295	71.32	gold quality
tonsil	UBERON:0002372	70.02	gold quality
liver	UBERON:0002107	69.74	gold quality
body of stomach	UBERON:0001161	69.70	gold quality
heart	UBERON:0000948	69.45	gold quality
ectocervix	UBERON:0012249	69.33	gold quality
ascending aorta	UBERON:0001496	69.10	gold quality
right atrium auricular region	UBERON:0006631	68.99	gold quality
right adrenal gland cortex	UBERON:0035827	68.96	gold quality
skin of abdomen	UBERON:0001416	68.69	gold quality
right coronary artery	UBERON:0001625	68.64	gold quality
thoracic aorta	UBERON:0001515	68.50	gold quality
adult mammalian kidney	UBERON:0000082	68.43	gold quality
subcutaneous adipose tissue	UBERON:0002190	68.43	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.44

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.