MIR548O2

Summary

MIR548O2 (microRNA 548o-2, HGNC:41882) is a microRNA gene on chromosome 20q11.23.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616190 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41882
Approved symbol	MIR548O2
Name	microRNA 548o-2
Location	20q11.23
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-548o-2
Ensembl gene	ENSG00000275453
Ensembl biotype	miRNA
Entrez	100616190
RNAcentral	URS000075BCBF — ncRNA, 70 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000616090

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000616090 — 1 exons

Exon	Start	End
ENSE00003724045	38516563	38516632

Expression profiles

Bgee: expression breadth broad, 55 present calls, max score 81.98.

Top tissues by expression

55 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
liver	UBERON:0002107	81.98	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	81.55	gold quality
endometrium	UBERON:0001295	78.77	gold quality
heart left ventricle	UBERON:0002084	75.13	gold quality
blood	UBERON:0000178	74.45	gold quality
gastrocnemius	UBERON:0001388	71.78	gold quality
Brodmann (1909) area 9	UBERON:0013540	71.69	gold quality
heart	UBERON:0000948	70.98	gold quality
monocyte	CL:0000576	70.39	gold quality
calcaneal tendon	UBERON:0003701	70.27	gold quality
ascending aorta	UBERON:0001496	69.27	gold quality
muscle layer of sigmoid colon	UBERON:0035805	69.22	gold quality
thoracic aorta	UBERON:0001515	69.08	gold quality
lower esophagus muscularis layer	UBERON:0035833	68.94	gold quality
body of pancreas	UBERON:0001150	68.49	gold quality
left lobe of thyroid gland	UBERON:0001120	68.28	gold quality
stomach	UBERON:0000945	67.66	gold quality
body of stomach	UBERON:0001161	67.29	gold quality
fundus of stomach	UBERON:0001160	67.22	gold quality
thoracic mammary gland	UBERON:0005200	67.11	gold quality
body of uterus	UBERON:0009853	66.89	gold quality
left adrenal gland cortex	UBERON:0035825	66.08	gold quality
myometrium	UBERON:0001296	65.73	gold quality
anterior cingulate cortex	UBERON:0009835	65.25	gold quality
tibial artery	UBERON:0007610	65.23	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	65.16	gold quality
transverse colon	UBERON:0001157	64.85	gold quality
minor salivary gland	UBERON:0001830	63.81	gold quality
skin of abdomen	UBERON:0001416	63.56	gold quality
subcutaneous adipose tissue	UBERON:0002190	63.56	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.32

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Paralogs (25): MIR548AA1 (ENSG00000207704), MIR579 (ENSG00000207956), MIR548P (ENSG00000221263), MIR548K (ENSG00000221333), MIR548F3 (ENSG00000221436), MIR548F1 (ENSG00000221594), MIR548N (ENSG00000221669), MIR548H3 (ENSG00000221698), MIR548AN (ENSG00000263515), MIR548X2 (ENSG00000263581), MIR548AX (ENSG00000263652), MIR548AS (ENSG00000263741), MIR548AV (ENSG00000263750), MIR548S (ENSG00000265056), MIR548AQ (ENSG00000265470), MIR548AG2 (ENSG00000265617), MIR548AJ1 (ENSG00000265669), MIR548AG1 (ENSG00000265829), MIR548X (ENSG00000265841), MIR548Z (ENSG00000266016), MIR548H5 (ENSG00000266807), MIR548AE1 (ENSG00000266808), MIR548AY (ENSG00000276147), MIR548AZ (ENSG00000276479), MIR548AH (ENSG00000283682)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.