MIR548P

Summary

MIR548P (microRNA 548p, HGNC:35351) is a microRNA gene on chromosome 5q21.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302288 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35351
Approved symbol	MIR548P
Name	microRNA 548p
Location	5q21.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-548p
Ensembl gene	ENSG00000221263
Ensembl biotype	miRNA
Entrez	100302288
RNAcentral	URS000075A50B — ncRNA, 84 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408336

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408336 — 1 exons

Exon	Start	End
ENSE00001564971	100816482	100816565

Expression profiles

Bgee: expression breadth broad, 77 present calls, max score 80.43.

Top tissues by expression

77 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
monocyte	CL:0000576	80.43	gold quality
adrenal tissue	UBERON:0018303	80.41	gold quality
vermiform appendix	UBERON:0001154	80.14	gold quality
blood	UBERON:0000178	79.79	gold quality
leukocyte	CL:0000738	79.70	gold quality
muscle of leg	UBERON:0001383	76.24	gold quality
gastrocnemius	UBERON:0001388	75.50	gold quality
granulocyte	CL:0000094	73.65	gold quality
endometrium	UBERON:0001295	73.59	gold quality
kidney	UBERON:0002113	72.26	gold quality
heart left ventricle	UBERON:0002084	71.76	gold quality
myometrium	UBERON:0001296	71.55	gold quality
adrenal gland	UBERON:0002369	71.19	gold quality
right adrenal gland cortex	UBERON:0035827	70.84	gold quality
heart	UBERON:0000948	70.78	gold quality
placenta	UBERON:0001987	70.78	gold quality
stomach	UBERON:0000945	70.70	gold quality
lymph node	UBERON:0000029	70.66	gold quality
Ammon’s horn	UBERON:0001954	70.59	gold quality
body of stomach	UBERON:0001161	68.16	gold quality
lung	UBERON:0002048	67.83	gold quality
left coronary artery	UBERON:0001626	67.32	gold quality
amygdala	UBERON:0001876	67.20	gold quality
rectum	UBERON:0001052	67.16	gold quality
lower esophagus muscularis layer	UBERON:0035833	67.07	gold quality
right lobe of liver	UBERON:0001114	67.05	gold quality
liver	UBERON:0002107	66.92	gold quality
transverse colon	UBERON:0001157	66.88	gold quality
substantia nigra	UBERON:0002038	66.52	gold quality
right atrium auricular region	UBERON:0006631	66.06	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.37

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• miR-548p regulates apoB secretion by targeting its mRNA degradation. (PMID:28336556)

Cross-species orthologs

0 orthologs

Paralogs (25): MIR548AA1 (ENSG00000207704), MIR579 (ENSG00000207956), MIR548K (ENSG00000221333), MIR548F3 (ENSG00000221436), MIR548F1 (ENSG00000221594), MIR548N (ENSG00000221669), MIR548H3 (ENSG00000221698), MIR548AN (ENSG00000263515), MIR548X2 (ENSG00000263581), MIR548AX (ENSG00000263652), MIR548AS (ENSG00000263741), MIR548AV (ENSG00000263750), MIR548S (ENSG00000265056), MIR548AQ (ENSG00000265470), MIR548AG2 (ENSG00000265617), MIR548AJ1 (ENSG00000265669), MIR548AG1 (ENSG00000265829), MIR548X (ENSG00000265841), MIR548Z (ENSG00000266016), MIR548H5 (ENSG00000266807), MIR548AE1 (ENSG00000266808), MIR548O2 (ENSG00000275453), MIR548AY (ENSG00000276147), MIR548AZ (ENSG00000276479), MIR548AH (ENSG00000283682)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.