MIR548Q

Summary

MIR548Q (microRNA 548q, HGNC:37312) is a microRNA gene on chromosome 10p13.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100313841 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:37312
Approved symbol	MIR548Q
Name	microRNA 548q
Location	10p13
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-548q
Ensembl gene	ENSG00000221331
Ensembl biotype	miRNA
Entrez	100313841
RNAcentral	URS000075D317 — miRNA, 100 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408404

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408404 — 1 exons

Exon	Start	End
ENSE00001565039	12725254	12725353

Expression profiles

Bgee: expression breadth broad, 87 present calls, max score 90.91.

Top tissues by expression

87 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	90.91	gold quality
monocyte	CL:0000576	82.32	gold quality
blood	UBERON:0000178	80.40	gold quality
islet of Langerhans	UBERON:0000006	76.89	gold quality
liver	UBERON:0002107	75.92	gold quality
calcaneal tendon	UBERON:0003701	75.83	gold quality
vermiform appendix	UBERON:0001154	75.06	gold quality
muscle of leg	UBERON:0001383	74.40	gold quality
left adrenal gland cortex	UBERON:0035825	73.31	gold quality
gastrocnemius	UBERON:0001388	72.49	gold quality
endometrium	UBERON:0001295	71.81	gold quality
left ovary	UBERON:0002119	71.66	gold quality
ovary	UBERON:0000992	71.22	gold quality
right ovary	UBERON:0002118	70.73	gold quality
kidney	UBERON:0002113	70.39	gold quality
stomach	UBERON:0000945	70.33	gold quality
body of uterus	UBERON:0009853	70.11	gold quality
adult mammalian kidney	UBERON:0000082	69.90	gold quality
left adrenal gland	UBERON:0001234	69.85	gold quality
body of pancreas	UBERON:0001150	69.84	gold quality
right lobe of liver	UBERON:0001114	69.75	gold quality
fallopian tube	UBERON:0003889	69.43	gold quality
left uterine tube	UBERON:0001303	69.40	gold quality
heart	UBERON:0000948	69.20	gold quality
endocervix	UBERON:0000458	68.99	gold quality
intestine	UBERON:0000160	68.80	gold quality
left coronary artery	UBERON:0001626	68.56	gold quality
corpus callosum	UBERON:0002336	68.49	gold quality
tibial artery	UBERON:0007610	68.39	gold quality
granulocyte	CL:0000094	68.10	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.57

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• miR-548q and miR-1185-1 levels in WBCs are biomarkers of response to weight-loss diets and could be involved in the regulation of the proinflammatory gene GSK3B. (PMID:31801236)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.