MIR548S

Summary

MIR548S (microRNA 548s, HGNC:38354) is a microRNA gene on chromosome 2p25.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422862 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38354
Approved symbol	MIR548S
Name	microRNA 548s
Location	2p25.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-548s
Ensembl gene	ENSG00000265056
Ensembl biotype	miRNA
Entrez	100422862
RNAcentral	URS000075B0EE — ncRNA, 82 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000581352

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000581352 — 1 exons

Exon	Start	End
ENSE00002695148	11767444	11767525

Expression profiles

Bgee: expression breadth broad, 68 present calls, max score 79.87.

Top tissues by expression

68 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
monocyte	CL:0000576	79.87	gold quality
adrenal tissue	UBERON:0018303	79.09	gold quality
blood	UBERON:0000178	76.46	gold quality
liver	UBERON:0002107	74.50	gold quality
muscle of leg	UBERON:0001383	73.71	gold quality
kidney	UBERON:0002113	73.59	gold quality
gastrocnemius	UBERON:0001388	73.51	gold quality
body of pancreas	UBERON:0001150	71.53	gold quality
heart left ventricle	UBERON:0002084	71.31	gold quality
stomach	UBERON:0000945	71.29	gold quality
ectocervix	UBERON:0012249	71.16	gold quality
adult mammalian kidney	UBERON:0000082	70.94	gold quality
heart	UBERON:0000948	70.61	gold quality
transverse colon	UBERON:0001157	69.61	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	69.35	gold quality
anterior cingulate cortex	UBERON:0009835	68.84	gold quality
body of stomach	UBERON:0001161	68.77	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	68.25	gold quality
esophagus mucosa	UBERON:0002469	67.40	gold quality
intestine	UBERON:0000160	67.35	gold quality
colon	UBERON:0001155	67.14	gold quality
esophagus	UBERON:0001043	67.13	gold quality
urinary bladder	UBERON:0001255	66.75	gold quality
tibial artery	UBERON:0007610	66.70	gold quality
hypothalamus	UBERON:0001898	66.46	gold quality
right atrium auricular region	UBERON:0006631	66.46	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.06	gold quality
ascending aorta	UBERON:0001496	65.90	gold quality
lung	UBERON:0002048	65.89	gold quality
right ovary	UBERON:0002118	65.50	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.86

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Paralogs (25): MIR548AA1 (ENSG00000207704), MIR579 (ENSG00000207956), MIR548P (ENSG00000221263), MIR548K (ENSG00000221333), MIR548F3 (ENSG00000221436), MIR548F1 (ENSG00000221594), MIR548N (ENSG00000221669), MIR548H3 (ENSG00000221698), MIR548AN (ENSG00000263515), MIR548X2 (ENSG00000263581), MIR548AX (ENSG00000263652), MIR548AS (ENSG00000263741), MIR548AV (ENSG00000263750), MIR548AQ (ENSG00000265470), MIR548AG2 (ENSG00000265617), MIR548AJ1 (ENSG00000265669), MIR548AG1 (ENSG00000265829), MIR548X (ENSG00000265841), MIR548Z (ENSG00000266016), MIR548H5 (ENSG00000266807), MIR548AE1 (ENSG00000266808), MIR548O2 (ENSG00000275453), MIR548AY (ENSG00000276147), MIR548AZ (ENSG00000276479), MIR548AH (ENSG00000283682)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.