MIR548T

Summary

MIR548T (microRNA 548t, HGNC:38298) is a microRNA gene on chromosome 4q34.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422849 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38298
Approved symbol	MIR548T
Name	microRNA 548t
Location	4q34.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-548t
Ensembl gene	ENSG00000221296
Ensembl biotype	miRNA
Entrez	100422849
RNAcentral	URS000075BD13 — miRNA, 74 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408369

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408369 — 1 exons

Exon	Start	End
ENSE00001565004	173268160	173268233

Expression profiles

Bgee: expression breadth broad, 65 present calls, max score 81.77.

Top tissues by expression

65 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	81.77	gold quality
kidney	UBERON:0002113	77.64	gold quality
blood	UBERON:0000178	76.96	gold quality
endometrium	UBERON:0001295	76.56	gold quality
calcaneal tendon	UBERON:0003701	75.78	gold quality
bone marrow	UBERON:0002371	74.95	gold quality
stomach	UBERON:0000945	73.45	gold quality
gastrocnemius	UBERON:0001388	72.30	gold quality
body of pancreas	UBERON:0001150	72.26	gold quality
monocyte	CL:0000576	71.88	gold quality
colon	UBERON:0001155	70.18	gold quality
fallopian tube	UBERON:0003889	69.33	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	69.06	gold quality
intestine	UBERON:0000160	69.04	gold quality
adult mammalian kidney	UBERON:0000082	68.72	gold quality
heart	UBERON:0000948	68.24	gold quality
heart left ventricle	UBERON:0002084	68.24	gold quality
transverse colon	UBERON:0001157	68.22	gold quality
body of stomach	UBERON:0001161	67.00	gold quality
tibial artery	UBERON:0007610	66.95	gold quality
thoracic aorta	UBERON:0001515	66.37	gold quality
ascending aorta	UBERON:0001496	66.09	gold quality
anterior cingulate cortex	UBERON:0009835	65.78	gold quality
right atrium auricular region	UBERON:0006631	65.76	gold quality
myometrium	UBERON:0001296	65.55	gold quality
left adrenal gland	UBERON:0001234	65.43	gold quality
muscle layer of sigmoid colon	UBERON:0035805	65.38	gold quality
liver	UBERON:0002107	65.10	gold quality
left ovary	UBERON:0002119	64.56	gold quality
amygdala	UBERON:0001876	64.48	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.49

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.