MIR548U

Summary

MIR548U (microRNA 548u, HGNC:38316) is a microRNA gene on chromosome 6p11.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422884 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38316
Approved symbol	MIR548U
Name	microRNA 548u
Location	6p11.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-548u
Ensembl gene	ENSG00000212017
Ensembl biotype	miRNA
Entrez	100422884
RNAcentral	URS000075BB3E — miRNA, 81 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000390728

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000390728 — 1 exons

Exon	Start	End
ENSE00001508405	57390132	57390212

Expression profiles

Bgee: expression breadth broad, 82 present calls, max score 98.17.

Top tissues by expression

82 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	98.17	gold quality
calcaneal tendon	UBERON:0003701	87.39	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	85.56	gold quality
monocyte	CL:0000576	79.48	gold quality
blood	UBERON:0000178	79.24	gold quality
islet of Langerhans	UBERON:0000006	77.12	gold quality
adrenal tissue	UBERON:0018303	76.56	gold quality
stomach	UBERON:0000945	76.48	gold quality
liver	UBERON:0002107	74.40	gold quality
gastrocnemius	UBERON:0001388	74.16	gold quality
endometrium	UBERON:0001295	72.55	gold quality
body of stomach	UBERON:0001161	71.96	gold quality
right lobe of liver	UBERON:0001114	71.11	gold quality
kidney	UBERON:0002113	70.35	gold quality
lung	UBERON:0002048	70.29	gold quality
endocervix	UBERON:0000458	70.00	gold quality
heart left ventricle	UBERON:0002084	69.92	gold quality
adult mammalian kidney	UBERON:0000082	69.66	gold quality
heart	UBERON:0000948	68.76	gold quality
intestine	UBERON:0000160	67.74	gold quality
rectum	UBERON:0001052	67.32	gold quality
colon	UBERON:0001155	67.21	gold quality
putamen	UBERON:0001874	67.06	gold quality
saliva-secreting gland	UBERON:0001044	66.66	gold quality
body of pancreas	UBERON:0001150	66.59	gold quality
left adrenal gland	UBERON:0001234	66.42	gold quality
ascending aorta	UBERON:0001496	66.27	gold quality
tibial artery	UBERON:0007610	66.22	gold quality
right frontal lobe	UBERON:0002810	65.88	gold quality
minor salivary gland	UBERON:0001830	65.83	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.77

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.