MIR548V

Summary

MIR548V (microRNA 548v, HGNC:38302) is a microRNA gene on chromosome 8p22.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422850 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38302
Approved symbol	MIR548V
Name	microRNA 548v
Location	8p22
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-548v
Ensembl gene	ENSG00000265520
Ensembl biotype	miRNA
Entrez	100422850
RNAcentral	URS000075B80E — miRNA, 80 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000584165

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000584165 — 1 exons

Exon	Start	End
ENSE00002710647	17681578	17681657

Expression profiles

Bgee: expression breadth ubiquitous, 103 present calls, max score 96.54.

Top tissues by expression

103 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
corpus callosum	UBERON:0002336	96.54	gold quality
sural nerve	UBERON:0015488	94.23	gold quality
calcaneal tendon	UBERON:0003701	90.96	gold quality
adrenal tissue	UBERON:0018303	90.53	gold quality
vermiform appendix	UBERON:0001154	82.47	gold quality
duodenum	UBERON:0002114	82.27	gold quality
blood	UBERON:0000178	80.95	gold quality
liver	UBERON:0002107	79.84	gold quality
adult mammalian kidney	UBERON:0000082	77.32	gold quality
endometrium	UBERON:0001295	77.17	gold quality
kidney	UBERON:0002113	77.04	gold quality
muscle of leg	UBERON:0001383	76.61	gold quality
placenta	UBERON:0001987	76.51	gold quality
fundus of stomach	UBERON:0001160	74.96	gold quality
gastrocnemius	UBERON:0001388	74.83	gold quality
lower esophagus mucosa	UBERON:0035834	74.48	gold quality
stomach	UBERON:0000945	74.39	gold quality
rectum	UBERON:0001052	73.95	gold quality
prefrontal cortex	UBERON:0000451	73.78	gold quality
monocyte	CL:0000576	73.09	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	72.98	gold quality
pancreas	UBERON:0001264	72.91	gold quality
body of pancreas	UBERON:0001150	72.64	gold quality
islet of Langerhans	UBERON:0000006	72.42	gold quality
right lobe of liver	UBERON:0001114	72.07	gold quality
adrenal gland	UBERON:0002369	71.48	gold quality
lymph node	UBERON:0000029	71.46	gold quality
heart	UBERON:0000948	71.40	gold quality
heart left ventricle	UBERON:0002084	70.73	gold quality
body of stomach	UBERON:0001161	70.48	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.55

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• hsa-miR-548v controls the viscoelastic properties of human cardiomyocytes and improves their relaxation rates. (PMID:38165745)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.