MIR548W

Summary

MIR548W (microRNA 548w, HGNC:38255) is a microRNA gene on chromosome 16p12.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422923 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38255
Approved symbol	MIR548W
Name	microRNA 548w
Location	16p12.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-548w
Ensembl gene	ENSG00000265005
Ensembl biotype	miRNA
Entrez	100422923
RNAcentral	URS000075E3DF — miRNA, 74 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000581970

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000581970 — 1 exons

Exon	Start	End
ENSE00002686977	26025237	26025310

Expression profiles

Bgee: expression breadth broad, 56 present calls, max score 76.86.

Top tissues by expression

56 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
monocyte	CL:0000576	76.86	gold quality
endometrium	UBERON:0001295	72.03	gold quality
stomach	UBERON:0000945	71.13	gold quality
heart	UBERON:0000948	70.47	gold quality
endocervix	UBERON:0000458	70.14	gold quality
blood	UBERON:0000178	69.63	gold quality
rectum	UBERON:0001052	68.95	gold quality
gastrocnemius	UBERON:0001388	68.62	gold quality
body of stomach	UBERON:0001161	68.46	gold quality
Brodmann (1909) area 9	UBERON:0013540	67.81	gold quality
heart left ventricle	UBERON:0002084	67.55	gold quality
hypothalamus	UBERON:0001898	67.13	gold quality
skin of abdomen	UBERON:0001416	66.04	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.04	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	65.93	gold quality
esophagus	UBERON:0001043	65.87	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	65.63	gold quality
ascending aorta	UBERON:0001496	65.23	gold quality
Ammon’s horn	UBERON:0001954	65.15	gold quality
esophagus mucosa	UBERON:0002469	64.96	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	64.84	gold quality
corpus callosum	UBERON:0002336	64.79	gold quality
myometrium	UBERON:0001296	64.57	gold quality
subcutaneous adipose tissue	UBERON:0002190	64.56	gold quality
tibial artery	UBERON:0007610	64.48	gold quality
omental fat pad	UBERON:0010414	64.37	gold quality
right atrium auricular region	UBERON:0006631	64.27	gold quality
transverse colon	UBERON:0001157	63.21	gold quality
colon	UBERON:0001155	63.11	gold quality
nucleus accumbens	UBERON:0001882	62.72	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.49

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.