MIR548X

Summary

MIR548X (microRNA 548x, HGNC:38248) is a microRNA gene on chromosome 21q21.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422920 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38248
Approved symbol	MIR548X
Name	microRNA 548x
Location	21q21.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-548x
Ensembl gene	ENSG00000265841
Ensembl biotype	miRNA
Entrez	100422920
RNAcentral	URS000075D953 — ncRNA, 75 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000580069

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000580069 — 1 exons

Exon	Start	End
ENSE00002731930	18686090	18686164

Expression profiles

Bgee: expression breadth tissue_specific, 5 present calls, max score 76.31.

Top tissues by expression

5 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
stomach	UBERON:0000945	76.31	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	72.44	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	65.20	gold quality
left ovary	UBERON:0002119	59.53	gold quality
right frontal lobe	UBERON:0002810	58.21	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.33

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Mesenchymal stem cell-derived exosomal miR-548x-3p inhibits pyroptosis of vascular endothelial cells through HMGB1 in heat stroke. (PMID:37757977)

Cross-species orthologs

0 orthologs

Paralogs (25): MIR548AA1 (ENSG00000207704), MIR579 (ENSG00000207956), MIR548P (ENSG00000221263), MIR548K (ENSG00000221333), MIR548F3 (ENSG00000221436), MIR548F1 (ENSG00000221594), MIR548N (ENSG00000221669), MIR548H3 (ENSG00000221698), MIR548AN (ENSG00000263515), MIR548X2 (ENSG00000263581), MIR548AX (ENSG00000263652), MIR548AS (ENSG00000263741), MIR548AV (ENSG00000263750), MIR548S (ENSG00000265056), MIR548AQ (ENSG00000265470), MIR548AG2 (ENSG00000265617), MIR548AJ1 (ENSG00000265669), MIR548AG1 (ENSG00000265829), MIR548Z (ENSG00000266016), MIR548H5 (ENSG00000266807), MIR548AE1 (ENSG00000266808), MIR548O2 (ENSG00000275453), MIR548AY (ENSG00000276147), MIR548AZ (ENSG00000276479), MIR548AH (ENSG00000283682)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.