MIR548X2

Summary

MIR548X2 (microRNA 548x-2, HGNC:41734) is a microRNA gene on chromosome 13q21.32.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616302 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41734
Approved symbol	MIR548X2
Name	microRNA 548x-2
Location	13q21.32
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-548x-2
Ensembl gene	ENSG00000263581
Ensembl biotype	miRNA
Entrez	100616302
RNAcentral	URS000075BEA9 — miRNA, 100 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000579776

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000579776 — 1 exons

Exon	Start	End
ENSE00002720302	65966330	65966429

Expression profiles

Bgee: expression breadth broad, 90 present calls, max score 95.69.

Top tissues by expression

90 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
corpus callosum	UBERON:0002336	95.69	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	89.11	gold quality
kidney	UBERON:0002113	84.44	gold quality
calcaneal tendon	UBERON:0003701	84.44	gold quality
blood	UBERON:0000178	81.46	gold quality
adrenal tissue	UBERON:0018303	80.49	gold quality
stomach	UBERON:0000945	79.10	gold quality
bone marrow	UBERON:0002371	77.66	gold quality
duodenum	UBERON:0002114	77.50	gold quality
endometrium	UBERON:0001295	77.03	gold quality
monocyte	CL:0000576	76.92	gold quality
muscle of leg	UBERON:0001383	76.28	gold quality
islet of Langerhans	UBERON:0000006	76.05	gold quality
apex of heart	UBERON:0002098	75.88	gold quality
liver	UBERON:0002107	74.75	gold quality
gastrocnemius	UBERON:0001388	74.33	gold quality
gall bladder	UBERON:0002110	74.01	gold quality
heart left ventricle	UBERON:0002084	72.96	gold quality
heart	UBERON:0000948	72.90	gold quality
endocervix	UBERON:0000458	72.75	gold quality
lung	UBERON:0002048	72.61	gold quality
adult mammalian kidney	UBERON:0000082	71.54	gold quality
body of pancreas	UBERON:0001150	71.39	gold quality
prefrontal cortex	UBERON:0000451	71.02	gold quality
right atrium auricular region	UBERON:0006631	70.89	gold quality
body of stomach	UBERON:0001161	70.54	gold quality
lymph node	UBERON:0000029	70.36	gold quality
left uterine tube	UBERON:0001303	70.02	gold quality
intestine	UBERON:0000160	69.98	gold quality
ascending aorta	UBERON:0001496	69.73	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.49

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Paralogs (25): MIR548AA1 (ENSG00000207704), MIR579 (ENSG00000207956), MIR548P (ENSG00000221263), MIR548K (ENSG00000221333), MIR548F3 (ENSG00000221436), MIR548F1 (ENSG00000221594), MIR548N (ENSG00000221669), MIR548H3 (ENSG00000221698), MIR548AN (ENSG00000263515), MIR548AX (ENSG00000263652), MIR548AS (ENSG00000263741), MIR548AV (ENSG00000263750), MIR548S (ENSG00000265056), MIR548AQ (ENSG00000265470), MIR548AG2 (ENSG00000265617), MIR548AJ1 (ENSG00000265669), MIR548AG1 (ENSG00000265829), MIR548X (ENSG00000265841), MIR548Z (ENSG00000266016), MIR548H5 (ENSG00000266807), MIR548AE1 (ENSG00000266808), MIR548O2 (ENSG00000275453), MIR548AY (ENSG00000276147), MIR548AZ (ENSG00000276479), MIR548AH (ENSG00000283682)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.