MIR548Y

Summary

MIR548Y (microRNA 548y, HGNC:38980) is a microRNA gene on chromosome 14q21.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100500919 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38980
Approved symbol	MIR548Y
Name	microRNA 548y
Location	14q21.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-548y
Ensembl gene	ENSG00000263945
Ensembl biotype	miRNA
Entrez	100500919
RNAcentral	URS000075B1BC — miRNA, 110 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000582739

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000582739 — 1 exons

Exon	Start	End
ENSE00002695158	47760995	47761104

Expression profiles

Bgee: expression breadth broad, 80 present calls, max score 78.07.

Top tissues by expression

80 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	78.07	gold quality
monocyte	CL:0000576	77.63	gold quality
endometrium	UBERON:0001295	77.29	gold quality
stomach	UBERON:0000945	76.63	gold quality
kidney	UBERON:0002113	75.91	gold quality
adrenal tissue	UBERON:0018303	74.27	gold quality
right lobe of liver	UBERON:0001114	74.26	gold quality
liver	UBERON:0002107	74.24	gold quality
gastrocnemius	UBERON:0001388	74.07	gold quality
muscle of leg	UBERON:0001383	73.68	gold quality
bone marrow	UBERON:0002371	71.77	gold quality
islet of Langerhans	UBERON:0000006	71.47	gold quality
body of stomach	UBERON:0001161	70.98	gold quality
body of pancreas	UBERON:0001150	70.77	gold quality
heart	UBERON:0000948	70.47	gold quality
intestine	UBERON:0000160	70.04	gold quality
popliteal artery	UBERON:0002250	69.66	gold quality
tibial artery	UBERON:0007610	69.66	gold quality
calcaneal tendon	UBERON:0003701	69.61	gold quality
lung	UBERON:0002048	69.52	gold quality
colon	UBERON:0001155	69.51	gold quality
left coronary artery	UBERON:0001626	69.43	gold quality
ascending aorta	UBERON:0001496	69.33	gold quality
thoracic aorta	UBERON:0001515	68.97	gold quality
adrenal gland	UBERON:0002369	68.09	gold quality
minor salivary gland	UBERON:0001830	68.03	gold quality
right atrium auricular region	UBERON:0006631	67.94	gold quality
lower esophagus muscularis layer	UBERON:0035833	67.94	gold quality
urinary bladder	UBERON:0001255	67.80	gold quality
adult mammalian kidney	UBERON:0000082	67.35	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.31

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.