MIR548Z

Summary

MIR548Z (microRNA 548z, HGNC:38929) is a microRNA gene on chromosome 12q14.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100500856 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38929
Approved symbol	MIR548Z
Name	microRNA 548z
Location	12q14.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-548z
Ensembl gene	ENSG00000266016
Ensembl biotype	miRNA
Entrez	100500856
RNAcentral	URS000075D937 — miRNA, 97 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000584743

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000584743 — 1 exons

Exon	Start	End
ENSE00002710834	64622509	64622605

Expression profiles

Bgee: expression breadth ubiquitous, 107 present calls, max score 89.59.

Top tissues by expression

107 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	89.59	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	81.38	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	80.32	gold quality
calcaneal tendon	UBERON:0003701	79.81	gold quality
vermiform appendix	UBERON:0001154	78.45	gold quality
monocyte	CL:0000576	78.04	gold quality
leukocyte	CL:0000738	77.54	gold quality
corpus callosum	UBERON:0002336	77.35	gold quality
blood	UBERON:0000178	76.35	gold quality
endometrium	UBERON:0001295	74.38	gold quality
prefrontal cortex	UBERON:0000451	74.37	gold quality
granulocyte	CL:0000094	71.54	gold quality
placenta	UBERON:0001987	70.45	gold quality
muscle of leg	UBERON:0001383	70.12	gold quality
kidney	UBERON:0002113	69.30	gold quality
liver	UBERON:0002107	69.28	gold quality
gastrocnemius	UBERON:0001388	69.24	gold quality
rectum	UBERON:0001052	68.86	gold quality
cerebellar hemisphere	UBERON:0002245	68.74	gold quality
right hemisphere of cerebellum	UBERON:0014890	68.40	gold quality
stomach	UBERON:0000945	68.37	gold quality
lymph node	UBERON:0000029	67.91	gold quality
islet of Langerhans	UBERON:0000006	67.80	gold quality
fundus of stomach	UBERON:0001160	67.47	gold quality
left ovary	UBERON:0002119	67.30	gold quality
ovary	UBERON:0000992	67.18	gold quality
Brodmann (1909) area 9	UBERON:0013540	66.40	gold quality
bone marrow	UBERON:0002371	66.15	gold quality
adult mammalian kidney	UBERON:0000082	66.06	gold quality
heart	UBERON:0000948	65.98	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Paralogs (25): MIR548AA1 (ENSG00000207704), MIR579 (ENSG00000207956), MIR548P (ENSG00000221263), MIR548K (ENSG00000221333), MIR548F3 (ENSG00000221436), MIR548F1 (ENSG00000221594), MIR548N (ENSG00000221669), MIR548H3 (ENSG00000221698), MIR548AN (ENSG00000263515), MIR548X2 (ENSG00000263581), MIR548AX (ENSG00000263652), MIR548AS (ENSG00000263741), MIR548AV (ENSG00000263750), MIR548S (ENSG00000265056), MIR548AQ (ENSG00000265470), MIR548AG2 (ENSG00000265617), MIR548AJ1 (ENSG00000265669), MIR548AG1 (ENSG00000265829), MIR548X (ENSG00000265841), MIR548H5 (ENSG00000266807), MIR548AE1 (ENSG00000266808), MIR548O2 (ENSG00000275453), MIR548AY (ENSG00000276147), MIR548AZ (ENSG00000276479), MIR548AH (ENSG00000283682)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.