MIR549A

Summary

MIR549A (microRNA 549a, HGNC:32803) is a microRNA gene on chromosome 15q25.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 693132 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32803
Approved symbol	MIR549A
Name	microRNA 549a
Location	15q25.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-549
Ensembl gene	ENSG00000208003
Ensembl biotype	miRNA
Entrez	693132
RNAcentral	URS00006468AB — miRNA, 96 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385268

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385268 — 1 exons

Exon	Start	End
ENSE00001500274	80841978	80842073

Expression profiles

Bgee: expression breadth broad, 53 present calls, max score 82.16.

Top tissues by expression

53 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	82.16	gold quality
endometrium	UBERON:0001295	78.79	gold quality
gastrocnemius	UBERON:0001388	74.98	gold quality
muscle of leg	UBERON:0001383	73.96	gold quality
body of stomach	UBERON:0001161	73.03	gold quality
kidney	UBERON:0002113	72.67	gold quality
calcaneal tendon	UBERON:0003701	71.97	gold quality
lower esophagus muscularis layer	UBERON:0035833	71.18	gold quality
stomach	UBERON:0000945	71.15	gold quality
heart	UBERON:0000948	70.73	gold quality
right atrium auricular region	UBERON:0006631	70.28	gold quality
tibial artery	UBERON:0007610	69.04	gold quality
endocervix	UBERON:0000458	69.00	gold quality
intestine	UBERON:0000160	68.96	gold quality
left coronary artery	UBERON:0001626	68.37	gold quality
ascending aorta	UBERON:0001496	68.20	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	68.13	gold quality
thoracic aorta	UBERON:0001515	67.51	gold quality
esophagus mucosa	UBERON:0002469	67.28	gold quality
omental fat pad	UBERON:0010414	67.28	gold quality
fundus of stomach	UBERON:0001160	65.92	gold quality
left ovary	UBERON:0002119	65.83	gold quality
Ammon’s horn	UBERON:0001954	65.77	gold quality
left adrenal gland	UBERON:0001234	65.27	gold quality
pituitary gland	UBERON:0000007	64.94	gold quality
skin of leg	UBERON:0001511	64.78	gold quality
small intestine Peyer’s patch	UBERON:0003454	64.50	gold quality
prostate gland	UBERON:0002367	64.44	gold quality
skin of abdomen	UBERON:0001416	64.32	gold quality
vagina	UBERON:0000996	64.25	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.32

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.