MIR550A1

Summary

MIR550A1 (microRNA 550a-1, HGNC:32804) is a microRNA gene on chromosome 7p14.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 693133 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32804
Approved symbol	MIR550A1
Name	microRNA 550a-1
Location	7p14.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-550-1
Ensembl gene	ENSG00000207771
Ensembl biotype	miRNA
Entrez	693133
RNAcentral	URS0000652210 — miRNA, 97 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385037

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385037 — 1 exons

Exon	Start	End
ENSE00001808817	30289794	30289890

Expression profiles

Bgee: expression breadth broad, 93 present calls, max score 72.77.

Top tissues by expression

93 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
monocyte	CL:0000576	72.77	gold quality
bone marrow	UBERON:0002371	72.45	gold quality
vermiform appendix	UBERON:0001154	71.15	gold quality
calcaneal tendon	UBERON:0003701	69.07	gold quality
kidney	UBERON:0002113	67.75	gold quality
islet of Langerhans	UBERON:0000006	67.68	gold quality
liver	UBERON:0002107	67.50	gold quality
muscle of leg	UBERON:0001383	67.28	gold quality
blood	UBERON:0000178	67.20	gold quality
endometrium	UBERON:0001295	66.87	gold quality
adult mammalian kidney	UBERON:0000082	66.69	gold quality
stomach	UBERON:0000945	66.37	gold quality
gastrocnemius	UBERON:0001388	66.29	gold quality
endocervix	UBERON:0000458	65.02	gold quality
urinary bladder	UBERON:0001255	64.94	gold quality
adrenal tissue	UBERON:0018303	64.65	gold quality
body of stomach	UBERON:0001161	64.08	gold quality
body of pancreas	UBERON:0001150	63.80	gold quality
skin of abdomen	UBERON:0001416	63.37	gold quality
placenta	UBERON:0001987	63.23	gold quality
tibial artery	UBERON:0007610	62.84	gold quality
ectocervix	UBERON:0012249	62.77	gold quality
heart	UBERON:0000948	62.72	gold quality
fundus of stomach	UBERON:0001160	62.58	gold quality
right adrenal gland	UBERON:0001233	62.56	gold quality
heart left ventricle	UBERON:0002084	62.54	gold quality
right lobe of liver	UBERON:0001114	62.46	gold quality
right ovary	UBERON:0002118	62.16	gold quality
left uterine tube	UBERON:0001303	61.94	gold quality
gall bladder	UBERON:0002110	61.83	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 6)

• The novel connection between miR-550a-3p and ERK defines a new diagnostic and prognostic role for miR-550a-3p in breast cancer (PMID:27462780)
• miR-550a mediates the TNF-alpha-induced suppression of cyp27b1 expression in peripheral B cells of patients with diabetes, which can be blocked by inhibition of miR-550a. (PMID:27935135)
• Bone-related circulating miRNAs miR-29b-3p, miR-550a-3p and miR-324-3p are significantly associated to dynamic processes of bone, reflected by bone histomorphometry. . miRNAs miR-29b-3p, miR-550a-3p and miR-324-3p were recently found to discriminate patients with low-traumatic fractures and are therefore promising new biomarkers for osteoporosis diagnosis (PMID:29559644)
• Novel MicroRNA Biomarkers, miR-142-5p, miR-550a, miR-1826, and miR-1201, Were Identified for Primary Melanoma. (PMID:31526187)
• miR-550-1 functions as a tumor suppressor in acute myeloid leukemia via the hippo signaling pathway. (PMID:33061801)
• LINC00261/microRNA-550a-3p/SDPR axis affects the biological characteristics of breast cancer stem cells. (PMID:33274565)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.