MIR550A2

Summary

MIR550A2 (microRNA 550a-2, HGNC:32805) is a microRNA gene on chromosome 7p14.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 693134 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32805
Approved symbol	MIR550A2
Name	microRNA 550a-2
Location	7p14.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-550-2, hsa-mir-550a-2
Ensembl gene	ENSG00000207573
Ensembl biotype	miRNA
Entrez	693134
RNAcentral	URS000070ACB1 — miRNA, 97 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000384841

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000384841 — 1 exons

Exon	Start	End
ENSE00001808098	32732981	32733077

Expression profiles

Bgee: expression breadth broad, 85 present calls, max score 71.59.

Top tissues by expression

85 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
kidney	UBERON:0002113	71.59	gold quality
monocyte	CL:0000576	69.61	gold quality
right coronary artery	UBERON:0001625	68.14	gold quality
adrenal tissue	UBERON:0018303	67.99	gold quality
sural nerve	UBERON:0015488	67.78	gold quality
bone marrow	UBERON:0002371	66.94	gold quality
adult mammalian kidney	UBERON:0000082	66.69	gold quality
islet of Langerhans	UBERON:0000006	66.26	gold quality
stomach	UBERON:0000945	64.67	gold quality
body of pancreas	UBERON:0001150	64.61	gold quality
blood	UBERON:0000178	64.14	gold quality
heart	UBERON:0000948	63.74	gold quality
heart left ventricle	UBERON:0002084	63.25	gold quality
placenta	UBERON:0001987	63.23	gold quality
muscle of leg	UBERON:0001383	62.79	gold quality
body of stomach	UBERON:0001161	62.52	gold quality
gastrocnemius	UBERON:0001388	62.34	gold quality
fundus of stomach	UBERON:0001160	62.32	gold quality
ectocervix	UBERON:0012249	61.63	gold quality
right adrenal gland	UBERON:0001233	61.49	gold quality
myometrium	UBERON:0001296	61.21	gold quality
left coronary artery	UBERON:0001626	61.04	gold quality
ascending aorta	UBERON:0001496	60.98	gold quality
right atrium auricular region	UBERON:0006631	60.75	gold quality
tibial artery	UBERON:0007610	60.51	gold quality
thoracic aorta	UBERON:0001515	60.49	gold quality
liver	UBERON:0002107	60.38	gold quality
Brodmann (1909) area 9	UBERON:0013540	59.92	gold quality
endometrium	UBERON:0001295	59.66	gold quality
corpus callosum	UBERON:0002336	59.45	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• The novel connection between miR-550a-3p and ERK defines a new diagnostic and prognostic role for miR-550a-3p in breast cancer (PMID:27462780)
• miR-550a mediates the TNF-alpha-induced suppression of cyp27b1 expression in peripheral B cells of patients with diabetes, which can be blocked by inhibition of miR-550a. (PMID:27935135)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.