MIR550A3

Summary

MIR550A3 (microRNA 550a-3, HGNC:41870) is a microRNA gene on chromosome 7p14.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616354 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41870
Approved symbol	MIR550A3
Name	microRNA 550a-3
Location	7p14.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-550a-3
Ensembl gene	ENSG00000212024
Ensembl biotype	miRNA
Entrez	100616354
RNAcentral	URS000075BC21 — miRNA, 95 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000390735

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000390735 — 1 exons

Exon	Start	End
ENSE00001809300	29680734	29680828

Expression profiles

Bgee: expression breadth broad, 49 present calls, max score 82.97.

Top tissues by expression

49 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	82.97	gold quality
gastrocnemius	UBERON:0001388	71.73	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	71.28	gold quality
heart left ventricle	UBERON:0002084	70.85	gold quality
body of stomach	UBERON:0001161	70.07	gold quality
skin of abdomen	UBERON:0001416	68.31	gold quality
tibial artery	UBERON:0007610	68.20	gold quality
lower esophagus muscularis layer	UBERON:0035833	67.89	gold quality
descending thoracic aorta	UBERON:0002345	67.67	gold quality
thoracic aorta	UBERON:0001515	67.26	gold quality
right atrium auricular region	UBERON:0006631	67.25	gold quality
prostate gland	UBERON:0002367	66.75	gold quality
left ovary	UBERON:0002119	66.66	gold quality
minor salivary gland	UBERON:0001830	66.61	gold quality
right frontal lobe	UBERON:0002810	66.46	gold quality
body of pancreas	UBERON:0001150	66.44	gold quality
ascending aorta	UBERON:0001496	66.41	gold quality
right ovary	UBERON:0002118	66.39	gold quality
left adrenal gland cortex	UBERON:0035825	66.37	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	66.28	gold quality
transverse colon	UBERON:0001157	65.24	gold quality
right adrenal gland cortex	UBERON:0035827	65.24	gold quality
putamen	UBERON:0001874	65.14	gold quality
omental fat pad	UBERON:0010414	64.85	gold quality
Ammon’s horn	UBERON:0001954	64.59	gold quality
esophagus mucosa	UBERON:0002469	64.44	gold quality
subcutaneous adipose tissue	UBERON:0002190	63.83	gold quality
left lobe of thyroid gland	UBERON:0001120	63.68	gold quality
anterior cingulate cortex	UBERON:0009835	63.30	gold quality
skin of leg	UBERON:0001511	63.16	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.49

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• miR-550a-3-5p acts as a tumor suppressor through the targeting of oncogenic YAP. (PMID:29844307)
• MiR-550a-3p promotes non-small cell lung cancer cell proliferation and metastasis through down-regulating TIMP2. (PMID:30024604)
• miR-550a-3/NFIC plays a driving role in esophageal squamous cell cancer cells proliferation and metastasis partly through EMT process. (PMID:32567032)
• MiR-550a-3p restores damaged vascular smooth muscle cells by inhibiting thrombomodulin in an in vitro atherosclerosis model. (PMID:35855629)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.