MIR551A

Summary

MIR551A (microRNA 551a, HGNC:32806) is a microRNA gene on chromosome 1p36.32.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 693135 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32806
Approved symbol	MIR551A
Name	microRNA 551a
Location	1p36.32
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-551a
Ensembl gene	ENSG00000207776
Ensembl biotype	miRNA
OMIM	615148
Entrez	693135
RNAcentral	URS000075E701 — miRNA, 96 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385042

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385042 — 1 exons

Exon	Start	End
ENSE00001500049	3560695	3560790

Expression profiles

Bgee: expression breadth broad, 38 present calls, max score 77.91.

Top tissues by expression

38 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
monocyte	CL:0000576	77.91	gold quality
bone marrow	UBERON:0002371	77.86	gold quality
stomach	UBERON:0000945	75.17	gold quality
blood	UBERON:0000178	74.98	gold quality
kidney	UBERON:0002113	72.49	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	70.31	gold quality
endometrium	UBERON:0001295	69.04	gold quality
anterior cingulate cortex	UBERON:0009835	68.10	gold quality
hypothalamus	UBERON:0001898	66.83	gold quality
amygdala	UBERON:0001876	66.58	gold quality
tibial artery	UBERON:0007610	66.53	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.12	gold quality
colon	UBERON:0001155	65.71	gold quality
muscle layer of sigmoid colon	UBERON:0035805	65.48	gold quality
left uterine tube	UBERON:0001303	65.14	gold quality
transverse colon	UBERON:0001157	64.76	gold quality
ascending aorta	UBERON:0001496	64.76	gold quality
lung	UBERON:0002048	64.46	gold quality
esophagus mucosa	UBERON:0002469	63.92	gold quality
omental fat pad	UBERON:0010414	63.69	gold quality
tibial nerve	UBERON:0001323	63.65	gold quality
skin of leg	UBERON:0001511	63.59	gold quality
caudate nucleus	UBERON:0001873	63.41	gold quality
small intestine Peyer’s patch	UBERON:0003454	63.35	gold quality
subcutaneous adipose tissue	UBERON:0002190	63.29	gold quality
spleen	UBERON:0002106	63.15	gold quality
fallopian tube	UBERON:0003889	62.89	gold quality
right lung	UBERON:0002167	62.78	gold quality
putamen	UBERON:0001874	62.09	gold quality
nucleus accumbens	UBERON:0001882	61.00	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.23

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• our findings suggest that miR-495 and miR-551a both act as tumor suppressors by targeting the PRL-3 oncogene and inhibiting gastric cancer cell migration and invasion. (PMID:22469786)
• Colorectal cancer primarily metastasizes to the liver; by functionally screening 661 microRNAs (miRNAs) in parallel during liver colonization, study identified miR-551a and miR-483 as robust endogenous suppressors of liver colonization and metastasis. (PMID:25601461)
• Correlation analysis showed a positive correlation between the expression level of plasma miR-21-3p and miR-551-5p in severe acute pancreatitis patients (PMID:32527354)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.