MIR551B

Summary

MIR551B (microRNA 551b, HGNC:32807) is a microRNA gene on chromosome 3q26.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 693136 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32807
Approved symbol	MIR551B
Name	microRNA 551b
Location	3q26.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-551b
Ensembl gene	ENSG00000207717
Ensembl biotype	miRNA
Entrez	693136
RNAcentral	URS000075D680 — miRNA, 96 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000384984

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000384984 — 1 exons

Exon	Start	End
ENSE00001499991	168551854	168551949

Expression profiles

Bgee: expression breadth broad, 20 present calls, max score 81.21.

Top tissues by expression

20 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
kidney	UBERON:0002113	81.21	gold quality
heart	UBERON:0000948	78.45	gold quality
blood	UBERON:0000178	78.03	gold quality
monocyte	CL:0000576	74.06	gold quality
lung	UBERON:0002048	73.69	gold quality
stomach	UBERON:0000945	72.75	gold quality
caudate nucleus	UBERON:0001873	72.09	gold quality
intestine	UBERON:0000160	71.97	gold quality
thoracic aorta	UBERON:0001515	71.83	gold quality
lower esophagus muscularis layer	UBERON:0035833	69.79	gold quality
esophagus mucosa	UBERON:0002469	68.10	gold quality
skin of abdomen	UBERON:0001416	66.23	gold quality
transverse colon	UBERON:0001157	65.32	gold quality
thyroid gland	UBERON:0002046	63.92	gold quality
skin of leg	UBERON:0001511	63.46	gold quality
left ovary	UBERON:0002119	62.45	gold quality
spleen	UBERON:0002106	62.34	gold quality
prostate gland	UBERON:0002367	59.75	gold quality
tibial nerve	UBERON:0001323	59.07	gold quality
right frontal lobe	UBERON:0002810	51.03	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.15

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 18)

• our results establish a pathway consisting of miR-551b/catalase/ROS that results in MUC1 overexpression, and intervention against this pathway could be exploited to overcome acquired chemoresistance. (PMID:25085901)
• In acute pancreatitis patients, a significant increase in miR-551-5p was observed when compared to control subjects. (PMID:26094040)
• MicroRNA-551b is highly expressed in hematopoietic stem cells and can serve as biomarker for relapse and poor prognosis in acute myeloid leukemia. (PMID:26108690)
• The role of miR-551b in cell proliferation, invasion, and drug resistance of ovarian cancer (PMID:27743201)
• Data suggest that miR-551b-3p functions as a tumour suppressor gene in gastric cancer, and its function is regulated by long noncoding RNAs (lncRNAs) SMARCC2/miR-551b-3p/transmembrane protease, serine 4 protein (TMPRSS4) axis. (PMID:29337109)
• Low miR551b expression is associated with cholangiocarcinoma. (PMID:29956786)
• miR-551b-5p may help in the stratification of patient with acute pancreatitis as endothelial dysfunction during acute pancreatitis is reflected by levels of miR-551b-5p 12. (PMID:29989302)
• Study showed a significant inverse correlation between miR-551b expression level and the histological grading of the cervical intraepithelial neoplasia, suggesting that the miR-551b could play an important role as oncosuppressor in the different stages of cervical dysplasia through the control on cell cycle. (PMID:30058680)
• Circulating miR-551b-5p was a novel promising biomarker for the detection of gastric cancer (PMID:30732916)
• MicroRNA-551b-3p inhibits tumour growth of human cholangiocarcinoma by targeting Cyclin D1. (PMID:31199052)
• Decreased expression of miR-551b predicts poor prognosis and promotes tumorigenesis by targeting PTP4A3 in human colorectal cancer. (PMID:31298325)
• miRNA551b-3p Activates an Oncostatin Signaling Module for the Progression of Triple-Negative Breast Cancer. (PMID:31875548)
• Correlation analysis showed a positive correlation between the expression level of plasma miR-21-3p and miR-551-5p in severe acute pancreatitis patients (PMID:32527354)
• Tumor-suppressive microRNA-551b-3p targets H6PD to inhibit gallbladder cancer progression. (PMID:33250514)
• miR-551b is Associated with the Poor Prognosis and Malignant Development of Papillary Thyroid Cancer Through Regulating ERBB4. (PMID:35130572)
• Exosomal microRNA-551b-3p from bone marrow-derived mesenchymal stromal cells inhibits breast cancer progression via regulating TRIM31/Akt signaling. (PMID:35941326)
• METTL9 derived circular RNA circ-METTL9 sponges miR-551b-5p to accelerate colorectal cancer progression by upregulating CDK6. (PMID:37158456)
• miR-148a and miR-551b-5p regulate inflammatory responses via regulating autophagy in acute pancreatitis. (PMID:38159552)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.