MIR552

Summary

MIR552 (microRNA 552, HGNC:32808) is a microRNA gene on chromosome 1p34.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 693137 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32808
Approved symbol	MIR552
Name	microRNA 552
Location	1p34.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-552
Ensembl gene	ENSG00000207941
Ensembl biotype	miRNA
Entrez	693137
RNAcentral	URS000071CA95 — miRNA, 96 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385206

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385206 — 1 exons

Exon	Start	End
ENSE00001500212	34669599	34669694

Expression profiles

Bgee: expression breadth broad, 19 present calls, max score 83.77.

Top tissues by expression

19 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
monocyte	CL:0000576	83.77	gold quality
gastrocnemius	UBERON:0001388	73.65	gold quality
blood	UBERON:0000178	70.37	gold quality
transverse colon	UBERON:0001157	70.33	gold quality
omental fat pad	UBERON:0010414	69.69	gold quality
colon	UBERON:0001155	68.86	gold quality
ascending aorta	UBERON:0001496	68.40	gold quality
skin of leg	UBERON:0001511	67.50	gold quality
right atrium auricular region	UBERON:0006631	66.89	gold quality
putamen	UBERON:0001874	64.42	gold quality
caudate nucleus	UBERON:0001873	64.28	gold quality
spleen	UBERON:0002106	63.48	gold quality
nucleus accumbens	UBERON:0001882	62.88	gold quality
muscle layer of sigmoid colon	UBERON:0035805	62.67	gold quality
amygdala	UBERON:0001876	62.29	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	62.14	gold quality
cerebellar hemisphere	UBERON:0002245	61.62	gold quality
right frontal lobe	UBERON:0002810	51.03	gold quality
left testis	UBERON:0004533	50.45	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.20

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 20)

• miR-552 and miR-592 were overexpressed in primary colorectal cancer relative to primary lung adenocarcinomas (PMID:24778034)
• Study showd three microRNAs miR-5000-3p, miR-5009-3P and miR-552 were found to be upregulated in side population cells of colon cancer cell lines . (PMID:24898979)
• MiR-552 with mutations in non-seed region losses its transcriptional, but retains its post-transcriptional repression to CYP2E1. In contrast, mutation in miR-552 seed sequence suppresses its inhibitory effects on CYP2E1 expression at protein (PMID:26926595)
• miR-552 is an oncomir able to promote colorectal cancer metastasis in part through a mechanism of targeting ADAM28. (PMID:27661126)
• Study revealed that the Wnt/beta-catenin signaling pathway and its major downstream target, c-Myc increased the miR552 levels and miR552 directly targets p53 tumor suppressor. miR552 may serve as an important link between functional loss of APC, leading to abnormal Wnt signals, and the absence of p53 protein in colorectal cancer. (PMID:30066856)
• MicroRNA-552 promotes hepatocellular carcinoma progression by downregulating WIF1 (PMID:30221686)
• The findings suggested that miR-552 promotes hepatocellular carcinoma oncogenesis and progression by inhibiting AJAP1 expression. (PMID:30597727)
• TIMP2 is a direct downstream target of miR-552 in osteosarcoma. (PMID:30765222)
• We demonstrated for the first time that miR-552 expression is upregulated in ovarian cancer tissues, and miR-552 shRNA silencing suppresses the growth and metastasis of ovarian cancer cells. Moreover, miR-552 promoted ovarian cancer cell progression by PTEN signaling pathway. (PMID:31815639)
• High miR-552 expression is associated with Proliferation, Migration, and Invasion of Gastric Cancer. (PMID:31958799)
• Linc00261 inhibits metastasis and the WNT signaling pathway of pancreatic cancer by regulating a miR5525p/FOXO3 axis. (PMID:32020223)
• miR-552 promotes laryngocarcinoma cells proliferation and metastasis by targeting p53 pathway. (PMID:32233984)
• Circular RNA SMARCA5 functions as an anti-tumor candidate in colon cancer by sponging microRNA-552. (PMID:33749508)
• FOXM1-induced miR-552 expression contributes to pancreatic cancer progression by targeting multiple tumor suppressor genes. (PMID:33867818)
• MiR-552-3p facilitated cell proliferation, migration and invasion by sponging Fibulin 5 in non-small cell lung cancer via activation of ERK/GSK3beta/beta-catenin signaling pathway. (PMID:34736163)
• ZNF8-miR-552-5p Axis Modulates ACSL4-Mediated Ferroptosis in Hepatocellular Carcinoma. (PMID:37126948)
• m[6]A-mediated LINC02038 inhibits colorectal cancer progression via regulation of the FAM172A/PI3K/AKT pathway via competitive binding with miR-552-5p. (PMID:37264959)
• MiR-552-3p Regulates Multiple Fibrotic and Inflammatory genes Concurrently in Hepatic Stellate Cells Improving NASH-associated Phenotypes. (PMID:37496991)
• miR-552 promotes the proliferation and metastasis of intrahepatic cholangiocarcinoma by targeting FOXO1. (PMID:37549804)
• Regulation of the PD-1/PD-L1 Axis and NK Cell Dysfunction by Exosomal miR-552-5p in Gastric Cancer. (PMID:39020183)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.