MIR553

Summary

MIR553 (microRNA 553, HGNC:32809) is a microRNA gene on chromosome 1p21.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 693138 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32809
Approved symbol	MIR553
Name	microRNA 553
Location	1p21.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-553
Ensembl gene	ENSG00000207750
Ensembl biotype	miRNA
Entrez	693138
RNAcentral	URS0000707BB9 — miRNA, 68 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385017

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385017 — 1 exons

Exon	Start	End
ENSE00001500024	100281241	100281308

Expression profiles

Bgee: expression breadth ubiquitous, 104 present calls, max score 93.88.

Top tissues by expression

104 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
calcaneal tendon	UBERON:0003701	93.88	gold quality
adrenal tissue	UBERON:0018303	87.83	gold quality
bone marrow	UBERON:0002371	85.89	gold quality
vermiform appendix	UBERON:0001154	83.59	gold quality
endometrium	UBERON:0001295	83.57	gold quality
corpus callosum	UBERON:0002336	83.39	gold quality
blood	UBERON:0000178	79.51	gold quality
muscle of leg	UBERON:0001383	77.89	gold quality
placenta	UBERON:0001987	77.71	gold quality
rectum	UBERON:0001052	77.32	gold quality
liver	UBERON:0002107	76.27	gold quality
monocyte	CL:0000576	75.18	gold quality
stomach	UBERON:0000945	74.82	gold quality
islet of Langerhans	UBERON:0000006	74.22	gold quality
fundus of stomach	UBERON:0001160	73.97	gold quality
kidney	UBERON:0002113	73.88	gold quality
lymph node	UBERON:0000029	73.81	gold quality
gastrocnemius	UBERON:0001388	73.27	gold quality
adult mammalian kidney	UBERON:0000082	72.77	gold quality
body of pancreas	UBERON:0001150	72.76	gold quality
body of stomach	UBERON:0001161	72.54	gold quality
adrenal gland	UBERON:0002369	72.35	gold quality
Ammon’s horn	UBERON:0001954	72.20	gold quality
smooth muscle tissue	UBERON:0001135	71.98	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	71.96	gold quality
prefrontal cortex	UBERON:0000451	71.90	gold quality
heart	UBERON:0000948	71.51	gold quality
heart left ventricle	UBERON:0002084	71.46	gold quality
intestine	UBERON:0000160	71.42	gold quality
colon	UBERON:0001155	70.93	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.47

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.