MIR554

Summary

MIR554 (microRNA 554, HGNC:32810) is a microRNA gene on chromosome 1q21.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 693139 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32810
Approved symbol	MIR554
Name	microRNA 554
Location	1q21.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-554
Ensembl gene	ENSG00000207606
Ensembl biotype	miRNA
Entrez	693139
RNAcentral	URS0000626340 — miRNA, 96 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000384874

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000384874 — 1 exons

Exon	Start	End
ENSE00001499881	151545796	151545891

Expression profiles

Bgee: expression breadth broad, 75 present calls, max score 85.18.

Top tissues by expression

75 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
calcaneal tendon	UBERON:0003701	85.18	gold quality
hypothalamus	UBERON:0001898	78.95	gold quality
blood	UBERON:0000178	77.49	gold quality
monocyte	CL:0000576	77.46	gold quality
stomach	UBERON:0000945	76.79	gold quality
placenta	UBERON:0001987	75.53	gold quality
adrenal tissue	UBERON:0018303	75.43	gold quality
kidney	UBERON:0002113	74.63	gold quality
ectocervix	UBERON:0012249	74.15	gold quality
prefrontal cortex	UBERON:0000451	72.91	gold quality
adult mammalian kidney	UBERON:0000082	72.14	gold quality
heart left ventricle	UBERON:0002084	72.12	gold quality
fundus of stomach	UBERON:0001160	71.98	gold quality
skin of abdomen	UBERON:0001416	71.87	gold quality
endometrium	UBERON:0001295	71.74	gold quality
zone of skin	UBERON:0000014	71.52	gold quality
islet of Langerhans	UBERON:0000006	71.48	gold quality
heart	UBERON:0000948	71.44	gold quality
skin of leg	UBERON:0001511	71.22	gold quality
intestine	UBERON:0000160	71.14	gold quality
body of pancreas	UBERON:0001150	70.88	gold quality
colon	UBERON:0001155	70.50	gold quality
body of stomach	UBERON:0001161	70.49	gold quality
vagina	UBERON:0000996	70.43	gold quality
left coronary artery	UBERON:0001626	70.43	gold quality
gastrocnemius	UBERON:0001388	70.01	gold quality
tibial artery	UBERON:0007610	69.53	gold quality
rectum	UBERON:0001052	69.49	gold quality
liver	UBERON:0002107	69.49	gold quality
right lung	UBERON:0002167	69.43	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.31

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.