MIR555

Summary

MIR555 (microRNA 555, HGNC:32811) is a microRNA gene on chromosome 1q22.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 693140 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32811
Approved symbol	MIR555
Name	microRNA 555
Location	1q22
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-555
Ensembl gene	ENSG00000283701
Ensembl biotype	miRNA
Entrez	693140
RNAcentral	URS000075E19D — miRNA, 96 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000384987

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000384987 — 1 exons

Exon	Start	End
ENSE00001499994	155346350	155346445

Expression profiles

Bgee: expression breadth broad, 96 present calls, max score 82.61.

Top tissues by expression

96 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
calcaneal tendon	UBERON:0003701	82.61	gold quality
bone marrow	UBERON:0002371	78.06	gold quality
muscle of leg	UBERON:0001383	76.39	gold quality
gastrocnemius	UBERON:0001388	76.25	gold quality
monocyte	CL:0000576	75.90	gold quality
blood	UBERON:0000178	75.14	gold quality
islet of Langerhans	UBERON:0000006	74.68	gold quality
endometrium	UBERON:0001295	74.45	gold quality
liver	UBERON:0002107	73.68	gold quality
left uterine tube	UBERON:0001303	73.31	gold quality
body of pancreas	UBERON:0001150	73.30	gold quality
fundus of stomach	UBERON:0001160	73.08	gold quality
right atrium auricular region	UBERON:0006631	73.06	gold quality
left coronary artery	UBERON:0001626	72.74	gold quality
ectocervix	UBERON:0012249	72.44	gold quality
myometrium	UBERON:0001296	72.34	gold quality
heart	UBERON:0000948	71.99	gold quality
tibial artery	UBERON:0007610	71.63	gold quality
popliteal artery	UBERON:0002250	71.57	gold quality
body of stomach	UBERON:0001161	71.42	gold quality
stomach	UBERON:0000945	71.40	gold quality
adrenal tissue	UBERON:0018303	71.40	gold quality
skin of abdomen	UBERON:0001416	71.33	gold quality
heart left ventricle	UBERON:0002084	71.33	gold quality
urinary bladder	UBERON:0001255	71.32	gold quality
body of uterus	UBERON:0009853	71.16	gold quality
left ovary	UBERON:0002119	71.12	gold quality
vagina	UBERON:0000996	71.10	gold quality
ovary	UBERON:0000992	71.05	gold quality
ascending aorta	UBERON:0001496	71.01	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.28

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Host miR-555 reduced the level of heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C) required for poliovirus replication in the infected cells. (PMID:26683768)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.