MIR556

Summary

MIR556 (microRNA 556, HGNC:32812) is a microRNA gene on chromosome 1q23.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 693141 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32812
Approved symbol	MIR556
Name	microRNA 556
Location	1q23.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-556
Ensembl gene	ENSG00000207729
Ensembl biotype	miRNA
Entrez	693141
RNAcentral	URS00006C3A3C — miRNA, 95 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000384996

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000384996 — 1 exons

Exon	Start	End
ENSE00001500003	162342546	162342640

Expression profiles

Bgee: expression breadth broad, 67 present calls, max score 79.85.

Top tissues by expression

67 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
endometrium	UBERON:0001295	79.85	gold quality
monocyte	CL:0000576	79.63	gold quality
heart	UBERON:0000948	76.20	gold quality
liver	UBERON:0002107	75.45	gold quality
adrenal tissue	UBERON:0018303	73.95	gold quality
gastrocnemius	UBERON:0001388	73.02	gold quality
bone marrow	UBERON:0002371	72.69	gold quality
tibial artery	UBERON:0007610	71.84	gold quality
body of pancreas	UBERON:0001150	71.44	gold quality
kidney	UBERON:0002113	70.75	gold quality
putamen	UBERON:0001874	70.74	gold quality
body of stomach	UBERON:0001161	70.22	gold quality
right lobe of liver	UBERON:0001114	70.04	gold quality
right atrium auricular region	UBERON:0006631	70.04	gold quality
blood	UBERON:0000178	69.63	gold quality
right adrenal gland	UBERON:0001233	69.34	gold quality
muscle layer of sigmoid colon	UBERON:0035805	69.26	gold quality
stomach	UBERON:0000945	69.16	gold quality
colon	UBERON:0001155	68.80	gold quality
granulocyte	CL:0000094	68.73	gold quality
transverse colon	UBERON:0001157	68.48	gold quality
lung	UBERON:0002048	68.19	gold quality
minor salivary gland	UBERON:0001830	68.04	gold quality
ascending aorta	UBERON:0001496	66.92	gold quality
omental fat pad	UBERON:0010414	66.60	gold quality
skin of abdomen	UBERON:0001416	66.37	gold quality
adult mammalian kidney	UBERON:0000082	66.05	gold quality
hypothalamus	UBERON:0001898	65.78	gold quality
body of uterus	UBERON:0009853	65.78	gold quality
small intestine Peyer’s patch	UBERON:0003454	65.64	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.82

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 17)

• miR-556-5p functions as an onco-miRNA and participates in prostate cancer carcinogenesis by suppressing PPP2R2A expression. (PMID:26297546)
• Results suggest that microRNAs miR-221-5p, miR-380-3p, miR-556-5p, miR-758-3p and miR-3074-3p are potential diagnostic biomarkers of lupus nephritis in patients with systemic lupus erythematosus (SLE). (PMID:27835701)
• These findings suggest that DAB2IP is a direct target of miRNA-556-3p, and endogenous miRNA-556-3p expression shows inverse correlation with simultaneous DAB2IP expression in bladder cancer (BC)tissues and cells. miRNA-556-3p functions as a tumor promoter in tumorigenesis and metastasis of BC by targeting DAB2IP (PMID:28440444)
• this study indicated that a functional polymorphism of GSTM3 -rs1055259 reduced susceptibility of clear cell renal cell carcinoma in the Chinese population. It influenced GSTM3 protein synthesis by interfering miR-556 binding, subsequently suppressed ROS activity and clear cell renal cell carcinoma progression. (PMID:29569387)
• MicroRNA-556-3p blocked the translation of DAB2IP at mRNA level by directly binding to 3’UTR of DAB2IP, enhancing the proliferation of esophageal tumor cells. (PMID:30402845)
• SNHG1/miR-556-5p/TCF12 feedback loop enhances the tumorigenesis of meningioma through Wnt signaling pathway. (PMID:31692066)
• Knockdown of circ-ABCB10 promotes sensitivity of lung cancer cells to cisplatin via miR-556-3p/AK4 axis. (PMID:31931771)
• Down-regulation of miR-556-3p inhibits hemangioma cell proliferation and promotes apoptosis by targeting VEGFC. (PMID:33040837)
• Targeting a novel hsa_circ_0000520/miR-556-5p/NLRP3 pathway-mediated cell pyroptosis and inflammation attenuates ovalbumin (OVA)-induced allergic rhinitis (AR) in mice models. (PMID:34028600)
• CircDIP2C ameliorates oxidized low-density lipoprotein-induced cell dysfunction by binding to miR-556-5p to induce TET2 in human umbilical vein endothelial cells. (PMID:34147657)
• Knock-down of microRNA miR-556-5p increases cisplatin-sensitivity in non-small cell lung cancer (NSCLC) via activating NLR family pyrin domain containing 3 (NLRP3)-mediated pyroptotic cell death. (PMID:34488537)
• Circular RNA circHERC4 as a novel oncogenic driver to promote tumor metastasis via the miR-556-5p/CTBP2/E-cadherin axis in colorectal cancer. (PMID:34781990)
• N6-methyladenine- induced LINC00667 promoted breast cancer progression through m6A/KIAA1429 positive feedback loop. (PMID:36700472)
• Hsa_circ_0070661 inhibits cancer progression through miR-556-5p/TEK axis in lung adenocarcinoma. (PMID:37005879)
• Down-regulation of long noncoding RNA HULC inhibits the inflammatory response in ankylosing spondylitis by reducing miR-556-5p-mediated YAP1 expression. (PMID:37525215)
• circSLCO1B7 suppresses the malignant progression of hepatocellular carcinoma via the miR-556-3p/DAB2IP axis. (PMID:38015711)
• Circular RNA circ_0096041 promotes osteosarcoma cell proliferation and migration via sponging miR-556-5p and regulating LIN28A expression. (PMID:38430033)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.