MIR557

Summary

MIR557 (microRNA 557, HGNC:32813) is a microRNA gene on chromosome 1q24.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 693142 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32813
Approved symbol	MIR557
Name	microRNA 557
Location	1q24.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-557
Ensembl gene	ENSG00000207974
Ensembl biotype	miRNA
Entrez	693142
RNAcentral	URS000075A6B8 — miRNA, 98 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385239

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385239 — 1 exons

Exon	Start	End
ENSE00001500245	168375524	168375621

Expression profiles

Bgee: expression breadth broad, 39 present calls, max score 75.64.

Top tissues by expression

39 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	75.64	gold quality
monocyte	CL:0000576	73.86	gold quality
gastrocnemius	UBERON:0001388	72.90	gold quality
kidney	UBERON:0002113	72.21	gold quality
heart left ventricle	UBERON:0002084	71.77	gold quality
lung	UBERON:0002048	71.75	gold quality
urinary bladder	UBERON:0001255	69.82	gold quality
ascending aorta	UBERON:0001496	69.82	gold quality
body of uterus	UBERON:0009853	69.33	gold quality
thoracic aorta	UBERON:0001515	69.32	gold quality
endometrium	UBERON:0001295	68.77	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	68.67	gold quality
lower esophagus muscularis layer	UBERON:0035833	68.65	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	67.27	gold quality
tibial artery	UBERON:0007610	67.23	gold quality
small intestine Peyer’s patch	UBERON:0003454	67.17	gold quality
subcutaneous adipose tissue	UBERON:0002190	66.67	gold quality
transverse colon	UBERON:0001157	66.53	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	66.40	gold quality
myometrium	UBERON:0001296	65.95	gold quality
left coronary artery	UBERON:0001626	65.44	gold quality
endocervix	UBERON:0000458	65.39	gold quality
skin of abdomen	UBERON:0001416	65.28	gold quality
vagina	UBERON:0000996	65.26	gold quality
skin of leg	UBERON:0001511	64.66	gold quality
omental fat pad	UBERON:0010414	64.08	gold quality
prostate gland	UBERON:0002367	63.90	gold quality
ectocervix	UBERON:0012249	63.89	gold quality
esophagus mucosa	UBERON:0002469	63.75	gold quality
left ovary	UBERON:0002119	63.63	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.16

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• MicroRNA-557 might work as a tumor suppressor by negatively regulating the expression of lymphocyte enhancement factor 1 in lung cancer cells. (PMID:28639890)
• The role and mechanism of miR-557 in inhibiting the differentiation and maturation of megakaryocytes in immune thrombocytopenia. (PMID:33586614)
• circ_0058063 promotes breast cancer progression by upregulating DLGAP5 via sponging miR-557. (PMID:37334578)
• miR-557 inhibits hepatocellular carcinoma progression through Wnt/beta-catenin signaling pathway by targeting RAB10. (PMID:38364252)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.