MIR5571

Summary

MIR5571 (microRNA 5571, HGNC:43513) is a microRNA gene on chromosome 22q11.22.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100847006 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43513
Approved symbol	MIR5571
Name	microRNA 5571
Location	22q11.22
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-5571
Ensembl gene	ENSG00000264824
Ensembl biotype	miRNA
Entrez	100847006
RNAcentral	URS00007A3E72 — ncRNA, 113 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000577998

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000577998 — 1 exons

Exon	Start	End
ENSE00002720548	22886267	22886379

Expression profiles

Bgee: expression breadth broad, 24 present calls, max score 86.82.

Top tissues by expression

24 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	86.82	gold quality
tibial artery	UBERON:0007610	82.59	gold quality
stomach	UBERON:0000945	75.32	gold quality
tonsil	UBERON:0002372	70.16	gold quality
vagina	UBERON:0000996	67.38	gold quality
minor salivary gland	UBERON:0001830	67.32	gold quality
colon	UBERON:0001155	66.94	gold quality
transverse colon	UBERON:0001157	66.39	gold quality
small intestine Peyer’s patch	UBERON:0003454	66.23	gold quality
muscle layer of sigmoid colon	UBERON:0035805	65.00	gold quality
tibial nerve	UBERON:0001323	64.87	gold quality
right ovary	UBERON:0002118	64.73	gold quality
spleen	UBERON:0002106	64.11	gold quality
skin of leg	UBERON:0001511	63.80	gold quality
lung	UBERON:0002048	63.76	gold quality
prostate gland	UBERON:0002367	62.66	gold quality
skin of abdomen	UBERON:0001416	61.98	gold quality
anterior cingulate cortex	UBERON:0009835	61.70	gold quality
upper lobe of left lung	UBERON:0008952	61.52	gold quality
rectum	UBERON:0001052	61.16	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	55.03	gold quality
left testis	UBERON:0004533	51.49	gold quality
testis	UBERON:0000473	51.07	gold quality
right testis	UBERON:0004534	48.53	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.70

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• Analyses of miRNA expression profiles by sequencing indicate that miR-5571-3p and miR-135b-5p correlate with increased rheumatoid arthritis risk and activity. (PMID:30707326)
• Identification of Three Differentially Expressed miRNAs as Potential Biomarkers for Lung Adenocarcinoma Prognosis. (PMID:31976830)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.