MIR5579

Summary

MIR5579 (microRNA 5579, HGNC:43485) is a microRNA gene on chromosome 11q14.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100847000 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43485
Approved symbol	MIR5579
Name	microRNA 5579
Location	11q14.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-5579
Ensembl gene	ENSG00000266570
Ensembl biotype	miRNA
Entrez	100847000
RNAcentral	URS000075C089 — ncRNA, 58 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000580400

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000580400 — 1 exons

Exon	Start	End
ENSE00002729185	79422169	79422226

Expression profiles

Bgee: expression breadth broad, 46 present calls, max score 94.07.

Top tissues by expression

46 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	94.07	gold quality
heart	UBERON:0000948	82.48	gold quality
lung	UBERON:0002048	81.25	gold quality
blood	UBERON:0000178	78.37	gold quality
kidney	UBERON:0002113	77.99	gold quality
stomach	UBERON:0000945	77.93	gold quality
adult mammalian kidney	UBERON:0000082	71.60	gold quality
intestine	UBERON:0000160	70.58	gold quality
corpus callosum	UBERON:0002336	70.35	gold quality
right adrenal gland	UBERON:0001233	68.94	gold quality
Ammon’s horn	UBERON:0001954	68.44	gold quality
left coronary artery	UBERON:0001626	68.21	gold quality
lower esophagus muscularis layer	UBERON:0035833	68.08	gold quality
subcutaneous adipose tissue	UBERON:0002190	68.04	gold quality
putamen	UBERON:0001874	67.56	gold quality
anterior cingulate cortex	UBERON:0009835	67.52	gold quality
skin of leg	UBERON:0001511	67.36	gold quality
cerebellar hemisphere	UBERON:0002245	67.04	gold quality
amygdala	UBERON:0001876	66.80	gold quality
tibial nerve	UBERON:0001323	66.74	gold quality
ascending aorta	UBERON:0001496	66.48	gold quality
left ovary	UBERON:0002119	66.40	gold quality
esophagus mucosa	UBERON:0002469	66.29	gold quality
right frontal lobe	UBERON:0002810	66.00	gold quality
skin of abdomen	UBERON:0001416	65.90	gold quality
vagina	UBERON:0000996	65.88	gold quality
body of stomach	UBERON:0001161	65.76	gold quality
left adrenal gland cortex	UBERON:0035825	65.58	gold quality
descending thoracic aorta	UBERON:0002345	65.48	gold quality
caudate nucleus	UBERON:0001873	65.09	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.30

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.