MIR558

Summary

MIR558 (microRNA 558, HGNC:32814) is a microRNA gene on chromosome 2p22.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 693143 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32814
Approved symbol	MIR558
Name	microRNA 558
Location	2p22.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-558
Ensembl gene	ENSG00000207653
Ensembl biotype	miRNA
OMIM	616473
Entrez	693143
RNAcentral	URS00006DB970 — miRNA, 94 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000384920

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000384920 — 1 exons

Exon	Start	End
ENSE00001499927	32532153	32532246

Expression profiles

Bgee: expression breadth broad, 77 present calls, max score 77.97.

Top tissues by expression

77 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	77.97	gold quality
blood	UBERON:0000178	77.26	gold quality
adult mammalian kidney	UBERON:0000082	75.05	gold quality
muscle of leg	UBERON:0001383	73.85	gold quality
kidney	UBERON:0002113	73.65	gold quality
calcaneal tendon	UBERON:0003701	73.63	gold quality
monocyte	CL:0000576	73.58	gold quality
endometrium	UBERON:0001295	73.56	gold quality
gastrocnemius	UBERON:0001388	73.00	gold quality
stomach	UBERON:0000945	72.99	gold quality
corpus callosum	UBERON:0002336	72.82	gold quality
amygdala	UBERON:0001876	71.27	gold quality
adrenal gland	UBERON:0002369	71.06	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	70.98	gold quality
liver	UBERON:0002107	70.80	gold quality
heart	UBERON:0000948	70.72	gold quality
left coronary artery	UBERON:0001626	69.65	gold quality
body of pancreas	UBERON:0001150	69.57	gold quality
thoracic mammary gland	UBERON:0005200	69.55	gold quality
colon	UBERON:0001155	68.64	gold quality
lung	UBERON:0002048	68.52	gold quality
intestine	UBERON:0000160	68.29	gold quality
muscle layer of sigmoid colon	UBERON:0035805	68.07	gold quality
right atrium auricular region	UBERON:0006631	68.05	gold quality
transverse colon	UBERON:0001157	67.92	gold quality
body of stomach	UBERON:0001161	67.91	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.88	gold quality
tibial artery	UBERON:0007610	67.76	gold quality
heart left ventricle	UBERON:0002084	67.68	gold quality
popliteal artery	UBERON:0002250	67.63	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.31

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 11)

• cartilage homeostasis is influenced by miR-558 which directly targets cyclooxygenase-2 and regulates IL-1beta-stimulated catabolic effects in human chondrocytes (PMID:23611898)
• miRNA-558 promotes tumorigenesis and aggressiveness of neuroblastoma cells through activating the transcription of heparanase (PMID:25616966)
• miR-558 facilitates the expression of HIF-2alpha through binding to its 5’-UTR, thus promoting the tumorigenesis and aggressiveness of neuroblastoma (PMID:27276678)
• ATKK was validated as a target gene of miR-558, and upregulation of miR-558 was observed in radioresistant lung cancer cells. Additionally, ectopic overexpression of ATKK partially but significantly reduced the miR-558-induced radioresistance. (PMID:27485693)
• miR-558 facilitates the progression of gastric cancer through directly targeting the HPSE promoter to attenuate Smad4-mediated repression of HPSE expression. (PMID:27685626)
• Over-expression of circHIPK3 effectively inhibits migration, invasion, and angiogenesis of bladder cancer cells in vitro and suppresses bladder cancer growth and metastasis in vivo Mechanistic studies reveal that circHIPK3 contains two critical binding sites for the microRNA miR-558 and can abundantly sponge miR-558 to suppress the expression of heparanase (HPSE). (PMID:28794202)
• Upregulated long noncoding RNA Linc00261 in pre-eclampsia and its effect on trophoblast invasion and migration via regulating miR-558/TIMP4 signaling pathway. (PMID:30891826)
• A novel circular RNA, hsa_circ_0030998 suppresses lung cancer tumorigenesis and Taxol resistance by sponging miR-558. (PMID:33190405)
• miR-558 Reduces the Damage of HBE Cells Exposed to Cigarette Smoke Extract by Targeting TNFRSF1A and Inactivating TAK1/MAPK/NF-kappaB Pathway. (PMID:33459100)
• Circ-OPHN1 suppresses the proliferation, migration, and invasion of trophoblast cells through mediating miR-558/THBS2 axis. (PMID:35277867)
• Re-expression of circ_0043610 contributes to trophoblast dysfunction through the miR-558/RYBP pathway in preeclampsia. (PMID:35908953)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.