MIR5580

Summary

MIR5580 (microRNA 5580, HGNC:43482) is a microRNA gene on chromosome 14q22.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100847076 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43482
Approved symbol	MIR5580
Name	microRNA 5580
Location	14q22.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-5580
Ensembl gene	ENSG00000266431
Ensembl biotype	miRNA
Entrez	100847076
RNAcentral	URS000075CF5A — ncRNA, 58 nt, 5 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000580850

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000580850 — 1 exons

Exon	Start	End
ENSE00002717363	53948427	53948484

Expression profiles

Bgee: expression breadth broad, 32 present calls, max score 75.64.

Top tissues by expression

32 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right lobe of liver	UBERON:0001114	75.64	gold quality
gastrocnemius	UBERON:0001388	73.75	gold quality
monocyte	CL:0000576	73.05	gold quality
ascending aorta	UBERON:0001496	72.91	gold quality
right atrium auricular region	UBERON:0006631	71.77	gold quality
saliva-secreting gland	UBERON:0001044	70.53	gold quality
anterior cingulate cortex	UBERON:0009835	69.81	gold quality
stomach	UBERON:0000945	68.88	gold quality
right uterine tube	UBERON:0001302	68.71	gold quality
fallopian tube	UBERON:0003889	68.44	gold quality
minor salivary gland	UBERON:0001830	68.07	gold quality
right frontal lobe	UBERON:0002810	67.97	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	67.36	gold quality
transverse colon	UBERON:0001157	66.45	gold quality
muscle layer of sigmoid colon	UBERON:0035805	66.23	gold quality
body of stomach	UBERON:0001161	66.14	gold quality
esophagus mucosa	UBERON:0002469	66.02	gold quality
Brodmann (1909) area 9	UBERON:0013540	65.98	gold quality
left ovary	UBERON:0002119	63.85	gold quality
skin of abdomen	UBERON:0001416	63.71	gold quality
omental fat pad	UBERON:0010414	63.66	gold quality
cerebellar hemisphere	UBERON:0002245	63.59	gold quality
hypothalamus	UBERON:0001898	63.51	gold quality
spleen	UBERON:0002106	63.03	gold quality
prostate gland	UBERON:0002367	61.65	gold quality
body of uterus	UBERON:0009853	61.37	gold quality
small intestine Peyer’s patch	UBERON:0003454	61.15	gold quality
vagina	UBERON:0000996	61.06	gold quality
caudate nucleus	UBERON:0001873	60.95	gold quality
pituitary gland	UBERON:0000007	58.74	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.34

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• hsamiR55803p inhibits oral cancer cell viability, proliferation and migration by suppressing LAMC2. (PMID:33880581)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.