MIR5581

Summary

MIR5581 (microRNA 5581, HGNC:43527) is a microRNA gene on chromosome 1p34.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100847010 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43527
Approved symbol	MIR5581
Name	microRNA 5581
Location	1p34.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-5581
Ensembl gene	ENSG00000263675
Ensembl biotype	miRNA
Entrez	100847010
RNAcentral	URS000075EF33 — ncRNA, 60 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000580821

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000580821 — 1 exons

Exon	Start	End
ENSE00002716849	37500935	37500994

Expression profiles

Bgee: expression breadth ubiquitous, 114 present calls, max score 91.01.

Top tissues by expression

114 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
skeletal muscle tissue	UBERON:0001134	91.01	gold quality
right uterine tube	UBERON:0001302	89.20	gold quality
duodenum	UBERON:0002114	88.82	gold quality
endometrium	UBERON:0001295	87.57	gold quality
vermiform appendix	UBERON:0001154	86.68	gold quality
adrenal tissue	UBERON:0018303	86.62	gold quality
rectum	UBERON:0001052	84.88	gold quality
tonsil	UBERON:0002372	84.53	gold quality
apex of heart	UBERON:0002098	84.10	gold quality
lymph node	UBERON:0000029	82.87	gold quality
placenta	UBERON:0001987	82.56	gold quality
fundus of stomach	UBERON:0001160	81.76	gold quality
bone marrow	UBERON:0002371	81.67	gold quality
muscle of leg	UBERON:0001383	80.94	gold quality
stomach	UBERON:0000945	80.79	gold quality
blood	UBERON:0000178	80.76	gold quality
right coronary artery	UBERON:0001625	80.73	gold quality
prefrontal cortex	UBERON:0000451	80.61	gold quality
body of pancreas	UBERON:0001150	80.39	gold quality
body of stomach	UBERON:0001161	80.31	gold quality
monocyte	CL:0000576	80.19	gold quality
gastrocnemius	UBERON:0001388	80.00	gold quality
tibial nerve	UBERON:0001323	79.62	gold quality
pancreas	UBERON:0001264	79.50	gold quality
pituitary gland	UBERON:0000007	79.36	gold quality
small intestine	UBERON:0002108	79.34	gold quality
adenohypophysis	UBERON:0002196	79.34	gold quality
small intestine Peyer’s patch	UBERON:0003454	78.88	gold quality
right lobe of thyroid gland	UBERON:0001119	78.78	gold quality
heart left ventricle	UBERON:0002084	78.25	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Functionally, LINC00961 overexpression obviously inhibited cell proliferation, migration, and invasion in hepatocellular carcinoma cells. Mechanistically, LINC00961 regulated cardiolipin synthase 1 expression via sponging miR-5581-3p. (PMID:30825207)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.