MIR5582

Summary

MIR5582 (microRNA 5582, HGNC:43461) is a microRNA gene on chromosome 11p11.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100847020 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43461
Approved symbol	MIR5582
Name	microRNA 5582
Location	11p11.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-5582
Ensembl gene	ENSG00000263540
Ensembl biotype	miRNA
Entrez	100847020
RNAcentral	URS000075AF3A — miRNA, 68 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000579697

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000579697 — 1 exons

Exon	Start	End
ENSE00002692141	46753125	46753192

Expression profiles

Bgee: expression breadth broad, 73 present calls, max score 82.59.

Top tissues by expression

73 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
endometrium	UBERON:0001295	82.59	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	82.08	gold quality
monocyte	CL:0000576	79.78	gold quality
adrenal tissue	UBERON:0018303	77.82	gold quality
blood	UBERON:0000178	74.82	gold quality
heart left ventricle	UBERON:0002084	73.47	gold quality
gastrocnemius	UBERON:0001388	72.87	gold quality
right adrenal gland	UBERON:0001233	72.70	gold quality
islet of Langerhans	UBERON:0000006	71.86	gold quality
amygdala	UBERON:0001876	71.59	gold quality
stomach	UBERON:0000945	70.98	gold quality
kidney	UBERON:0002113	70.45	gold quality
left adrenal gland cortex	UBERON:0035825	69.62	gold quality
substantia nigra	UBERON:0002038	69.46	gold quality
body of stomach	UBERON:0001161	69.42	gold quality
tibial artery	UBERON:0007610	69.16	gold quality
right atrium auricular region	UBERON:0006631	68.79	gold quality
tonsil	UBERON:0002372	68.63	gold quality
body of pancreas	UBERON:0001150	68.37	gold quality
liver	UBERON:0002107	68.34	gold quality
ascending aorta	UBERON:0001496	68.08	gold quality
left adrenal gland	UBERON:0001234	68.06	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	66.98	gold quality
granulocyte	CL:0000094	66.62	gold quality
thoracic aorta	UBERON:0001515	66.61	gold quality
right lobe of liver	UBERON:0001114	66.50	gold quality
muscle layer of sigmoid colon	UBERON:0035805	66.50	gold quality
minor salivary gland	UBERON:0001830	66.30	gold quality
subcutaneous adipose tissue	UBERON:0002190	66.25	gold quality
anterior cingulate cortex	UBERON:0009835	66.23	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.41

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• miR-5582-5p induced apoptosis and cell cycle arrest in cancer cells, but not in normal cells. GAB1, SHC1, and CDK2 were identified as direct targets of miR-5582-5p. (PMID:27475256)
• miR-5582-3P reduces the TGFbeta/SMAD signaling pathway through downregulation of TGFbeta-R1, TGFbeta-R2, SMAD3, and SMAD4 transcripts. These data introduce miR-5582-3P as a potential tumor suppressors-miR. (PMID:30129155)
• LUCAT1 might be a significant biomarker to evaluate prognosis in breast cancer survivors. LUCAT1 increased BCCs stem-like properties and BCSCs stemness by competitively binding miR-5582-3p with TCF7L2 and enhancing the Wnt/beta-catenin signaling pathway. (PMID:31300015)
• We found that the three protein-coding genes functionally interact with targets of their intronic miRNAs, i.e., miR-3182, miR-6863, and miR-5582, in a tissue-specific pattern. (PMID:31464655)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.