MIR5583-1

Summary

MIR5583-1 (microRNA 5583-1, HGNC:43491) is a microRNA gene on chromosome 18q12.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100847025 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43491
Approved symbol	MIR5583-1
Name	microRNA 5583-1
Location	18q12.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-5583-1
Ensembl gene	ENSG00000266148
Ensembl biotype	miRNA
Entrez	100847025
RNAcentral	URS000075C048 — miRNA, 59 nt, 7 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000580941

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000580941 — 1 exons

Exon	Start	End
ENSE00002709626	39676721	39676779

Expression profiles

Bgee: expression breadth tissue_specific, 10 present calls, max score 73.30.

Top tissues by expression

10 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adult mammalian kidney	UBERON:0000082	73.30	gold quality
stomach	UBERON:0000945	72.71	gold quality
monocyte	CL:0000576	71.34	gold quality
esophagus mucosa	UBERON:0002469	67.52	gold quality
transverse colon	UBERON:0001157	67.49	gold quality
body of stomach	UBERON:0001161	65.15	gold quality
skin of abdomen	UBERON:0001416	57.09	gold quality
left testis	UBERON:0004533	50.46	gold quality
subcutaneous adipose tissue	UBERON:0002190	49.75	gold quality
right testis	UBERON:0004534	43.12	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.16

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.