MIR5584

Summary

MIR5584 (microRNA 5584, HGNC:43507) is a microRNA gene on chromosome 1p34.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100847089 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43507
Approved symbol	MIR5584
Name	microRNA 5584
Location	1p34.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-5584
Ensembl gene	ENSG00000263381
Ensembl biotype	miRNA
Entrez	100847089
RNAcentral	URS000075E3BF — ncRNA, 60 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000581357

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000581357 — 1 exons

Exon	Start	End
ENSE00002699305	44545493	44545552

Expression profiles

Bgee: expression breadth broad, 37 present calls, max score 84.89.

Top tissues by expression

37 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
duodenum	UBERON:0002114	84.89	gold quality
small intestine	UBERON:0002108	82.78	gold quality
blood	UBERON:0000178	79.34	gold quality
prefrontal cortex	UBERON:0000451	78.48	gold quality
ascending aorta	UBERON:0001496	75.50	gold quality
lung	UBERON:0002048	75.37	gold quality
gastrocnemius	UBERON:0001388	73.03	gold quality
tibial artery	UBERON:0007610	71.68	gold quality
corpus callosum	UBERON:0002336	69.84	gold quality
amygdala	UBERON:0001876	69.23	gold quality
Ammon’s horn	UBERON:0001954	69.10	gold quality
Brodmann (1909) area 9	UBERON:0013540	67.77	gold quality
skin of leg	UBERON:0001511	67.28	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	66.37	gold quality
muscle layer of sigmoid colon	UBERON:0035805	66.29	gold quality
substantia nigra	UBERON:0002038	66.10	gold quality
lower esophagus muscularis layer	UBERON:0035833	65.93	gold quality
brain	UBERON:0000955	65.73	gold quality
thoracic mammary gland	UBERON:0005200	65.52	gold quality
left lobe of thyroid gland	UBERON:0001120	65.26	gold quality
right hemisphere of cerebellum	UBERON:0014890	65.08	gold quality
hypothalamus	UBERON:0001898	64.94	gold quality
subcutaneous adipose tissue	UBERON:0002190	64.82	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	64.77	gold quality
putamen	UBERON:0001874	64.73	gold quality
cerebellar hemisphere	UBERON:0002245	64.72	gold quality
caudate nucleus	UBERON:0001873	64.70	gold quality
right frontal lobe	UBERON:0002810	64.02	gold quality
nucleus accumbens	UBERON:0001882	63.53	gold quality
omental fat pad	UBERON:0010414	63.52	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.49

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.