MIR5585

Summary

MIR5585 (microRNA 5585, HGNC:43452) is a microRNA gene on chromosome 1p35.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100847018 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43452
Approved symbol	MIR5585
Name	microRNA 5585
Location	1p35.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-5585
Ensembl gene	ENSG00000266203
Ensembl biotype	miRNA
Entrez	100847018
RNAcentral	URS000075C938 — ncRNA, 59 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000577515

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000577515 — 1 exons

Exon	Start	End
ENSE00002709089	32086949	32087007

Expression profiles

Bgee: expression breadth broad, 38 present calls, max score 83.12.

Top tissues by expression

38 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
liver	UBERON:0002107	83.12	gold quality
lung	UBERON:0002048	79.40	gold quality
gastrocnemius	UBERON:0001388	77.52	gold quality
heart left ventricle	UBERON:0002084	73.67	gold quality
blood	UBERON:0000178	72.99	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	72.70	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	72.53	gold quality
putamen	UBERON:0001874	71.67	gold quality
body of pancreas	UBERON:0001150	71.20	gold quality
body of stomach	UBERON:0001161	70.81	gold quality
tibial artery	UBERON:0007610	70.51	gold quality
lower esophagus muscularis layer	UBERON:0035833	69.70	gold quality
subcutaneous adipose tissue	UBERON:0002190	69.10	gold quality
esophagus mucosa	UBERON:0002469	68.96	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	68.25	gold quality
right atrium auricular region	UBERON:0006631	68.16	gold quality
ascending aorta	UBERON:0001496	67.53	gold quality
brain	UBERON:0000955	65.32	gold quality
adult mammalian kidney	UBERON:0000082	65.28	gold quality
skin of abdomen	UBERON:0001416	65.13	gold quality
substantia nigra	UBERON:0002038	65.00	gold quality
right hemisphere of cerebellum	UBERON:0014890	64.71	gold quality
amygdala	UBERON:0001876	64.51	gold quality
right lobe of thyroid gland	UBERON:0001119	64.43	gold quality
nucleus accumbens	UBERON:0001882	64.42	gold quality
cerebellar hemisphere	UBERON:0002245	64.07	gold quality
tibial nerve	UBERON:0001323	63.73	gold quality
muscle layer of sigmoid colon	UBERON:0035805	63.73	gold quality
anterior cingulate cortex	UBERON:0009835	63.36	gold quality
vagina	UBERON:0000996	62.85	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.64

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Groups of mRNAs in which the ordering of the miR-619-5p, miR-5095, miR-5096, and miR-5585-3p binding sites differ were established (PMID:25162022)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.