MIR5586

Summary

MIR5586 (microRNA 5586, HGNC:43493) is a microRNA gene on chromosome 14q23.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100847088 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43493
Approved symbol	MIR5586
Name	microRNA 5586
Location	14q23.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-5586
Ensembl gene	ENSG00000263629
Ensembl biotype	miRNA
Entrez	100847088
RNAcentral	URS000075BFAF — miRNA, 59 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000582927

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000582927 — 1 exons

Exon	Start	End
ENSE00002726825	59646962	59647020

Expression profiles

Bgee: expression breadth broad, 24 present calls, max score 77.38.

Top tissues by expression

24 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
stomach	UBERON:0000945	77.38	gold quality
blood	UBERON:0000178	75.70	gold quality
calcaneal tendon	UBERON:0003701	72.08	gold quality
islet of Langerhans	UBERON:0000006	71.93	gold quality
skin of abdomen	UBERON:0001416	70.50	gold quality
substantia nigra	UBERON:0002038	67.88	gold quality
tibial artery	UBERON:0007610	67.34	gold quality
intestine	UBERON:0000160	67.30	gold quality
skin of leg	UBERON:0001511	66.88	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	66.48	gold quality
pituitary gland	UBERON:0000007	65.96	gold quality
anterior cingulate cortex	UBERON:0009835	65.18	gold quality
nucleus accumbens	UBERON:0001882	64.29	gold quality
caudate nucleus	UBERON:0001873	64.17	gold quality
right hemisphere of cerebellum	UBERON:0014890	64.03	gold quality
subcutaneous adipose tissue	UBERON:0002190	64.01	gold quality
cerebellar hemisphere	UBERON:0002245	63.82	gold quality
thyroid gland	UBERON:0002046	63.18	gold quality
colon	UBERON:0001155	62.98	gold quality
tibial nerve	UBERON:0001323	62.58	gold quality
left lobe of thyroid gland	UBERON:0001120	61.50	gold quality
spleen	UBERON:0002106	56.22	gold quality
left testis	UBERON:0004533	45.99	gold quality
right testis	UBERON:0004534	43.94	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.82

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.